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Viruses 2009, 1(3), 780-801; https://doi.org/10.3390/v1030780

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights

Division of Medicine, Imperial College London, St. Mary’s Campus, Norfolk Place, London, W2 1PG, UK
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Received: 12 October 2009 / Revised: 28 October 2009 / Accepted: 6 November 2009 / Published: 6 November 2009
(This article belongs to the Special Issue Retroviral Enzymes)
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Abstract

Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising target for antiretroviral drug development and as a potential tool to improve safety of lentiviral vectors for use in gene therapy. Additionally, as a natural ligand of lentiviral IN proteins, LEDGF has been successfully used in structural biology studies of retroviral DNA integration. This review focuses on the structural aspects of the IN-LEDGF interaction and their functional consequences. View Full-Text
Keywords: retrovirus; integrase; host factors; protein-protein interaction retrovirus; integrase; host factors; protein-protein interaction
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Hare, S.; Cherepanov, P. The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights. Viruses 2009, 1, 780-801.

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