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Viruses 2009, 1(3), 780-801; doi:10.3390/v1030780

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights

Division of Medicine, Imperial College London, St. Mary’s Campus, Norfolk Place, London, W2 1PG, UK
* Author to whom correspondence should be addressed.
Received: 12 October 2009 / Revised: 28 October 2009 / Accepted: 6 November 2009 / Published: 6 November 2009
(This article belongs to the Special Issue Retroviral Enzymes)
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Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising target for antiretroviral drug development and as a potential tool to improve safety of lentiviral vectors for use in gene therapy. Additionally, as a natural ligand of lentiviral IN proteins, LEDGF has been successfully used in structural biology studies of retroviral DNA integration. This review focuses on the structural aspects of the IN-LEDGF interaction and their functional consequences.
Keywords: retrovirus; integrase; host factors; protein-protein interaction retrovirus; integrase; host factors; protein-protein interaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hare, S.; Cherepanov, P. The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights. Viruses 2009, 1, 780-801.

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