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Viruses 2010, 2(5), 1181-1184; doi:10.3390/v2051181

Special Issue: Retroviral Enzymes

Centro de Biología Molecular “Severo Ochoa” [Consejo Superior de Investigaciones Científicas (CSIC) & Universidad Autónoma de Madrid], Campus de Cantoblanco, 28049 Madrid, Spain
Received: 5 May 2010 / Accepted: 7 May 2010 / Published: 7 May 2010
(This article belongs to the Special Issue Retroviral Enzymes)
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The retroviral RNA genome encodes for three enzymes essential for virus replication: (i) the viral protease (PR), that converts the immature virion into a mature virus through the cleavage of precursor polypeptides; (ii) the reverse transcriptase (RT), responsible for the conversion of the single-stranded genomic RNA into double-stranded proviral DNA; and (iii) the integrase (IN) that inserts the proviral DNA into the host cell genome. All of them are important targets for therapeutic intervention. This Special Issue provides authoritative reviews on the most recent research towards a better understanding of structure-function relationships in retroviral enzymes. The Issue includes three reviews on retroviral PRs, seven on RT and reverse transcription, and four dedicated to viral integration. [...]
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Menéndez-Arias, L. Special Issue: Retroviral Enzymes. Viruses 2010, 2, 1181-1184.

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