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Viruses 2010, 2(1), 213-243; doi:10.3390/v2010213

Initiation of HIV Reverse Transcription

Architecture et Réactivité de l’ARN, Université de Strasbourg, CNRS, IBMC, 15 Rue René Descartes, 67084 Strasbourg cedex, France
Authors to whom correspondence should be addressed.
Received: 7 October 2009 / Revised: 8 January 2010 / Accepted: 13 January 2010 / Published: 18 January 2010
(This article belongs to the Special Issue Retroviral Enzymes)


Reverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the viral particle, leading to an RNA/protein complex with very specific structural and functional features, some of which being, in the case of HIV-1, linked to particular isolates. Recent understanding of the tight spatio-temporal regulation of reverse transcription and its importance for viral infectivity further points toward reverse transcription and potentially its initiation step as an important drug target.
Keywords: retrovirus; reverse transcriptase; tRNA retrovirus; reverse transcriptase; tRNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Isel, C.; Ehresmann, C.; Marquet, R. Initiation of HIV Reverse Transcription. Viruses 2010, 2, 213-243.

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