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Interactions of Host Proteins with the Murine Leukemia Virus Integrase
Brooklyn College of the City University of New York, Department of Biology, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
Columbia University College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, 701 West 168 Street, New York, NY 10028, USA
* Author to whom correspondence should be addressed.
Received: 25 March 2010; in revised form: 2 May 2010 / Accepted: 3 May 2010 / Published: 5 May 2010
Abstract: Retroviral infections cause a variety of cancers in animals and a number of diverse diseases in humans such as leukemia and acquired immune deficiency syndrome. Productive and efficient proviral integration is critical for retroviral function and is the key step in establishing a stable and productive infection, as well as the mechanism by which host genes are activated in leukemogenesis. Host factors are widely anticipated to be involved in all stages of the retroviral life cycle, and the identification of integrase interacting factors has the potential to increase our understanding of mechanisms by which the incoming virus might appropriate cellular proteins to target and capture host DNA sequences. Identification of MoMLV integrase interacting host factors may be key to designing efficient and benign retroviral-based gene therapy vectors; key to understanding the basic mechanism of integration; and key in designing efficient integrase inhibitors. In this review, we discuss current progress in the field of MoMLV integrase interacting proteins and possible roles for these proteins in integration.
Keywords: retroviruses; integrase; MoMLV
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Studamire, B.; Goff, S.P. Interactions of Host Proteins with the Murine Leukemia Virus Integrase. Viruses 2010, 2, 1110-1145.
Studamire B, Goff SP. Interactions of Host Proteins with the Murine Leukemia Virus Integrase. Viruses. 2010; 2(5):1110-1145.
Studamire, Barbara; Goff, Stephen P. 2010. "Interactions of Host Proteins with the Murine Leukemia Virus Integrase." Viruses 2, no. 5: 1110-1145.