Retroviral Integration Site Selection
AbstractThe stable insertion of a copy of their genome into the host cell genome is an essential step of the life cycle of retroviruses. The site of viral DNA integration, mediated by the viral-encoded integrase enzyme, has important consequences for both the virus and the host cell. The analysis of retroviral integration site distribution was facilitated by the availability of the human genome sequence, revealing the non-random feature of integration site selection and identifying different favored and disfavored genomic locations for individual retroviruses. This review will summarize the current knowledge about retroviral differences in their integration site preferences as well as the mechanisms involved in this process. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Desfarges, S.; Ciuffi, A. Retroviral Integration Site Selection. Viruses 2010, 2, 111-130.
Desfarges S, Ciuffi A. Retroviral Integration Site Selection. Viruses. 2010; 2(1):111-130.Chicago/Turabian Style
Desfarges, Sébastien; Ciuffi, Angela. 2010. "Retroviral Integration Site Selection." Viruses 2, no. 1: 111-130.