Viruses 2010, 2(1), 111-130; doi:10.3390/v2010111
Review

Retroviral Integration Site Selection

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Received: 8 October 2009; in revised form: 21 December 2009 / Accepted: 5 January 2010 / Published: 12 January 2010
(This article belongs to the Special Issue Retroviral Enzymes)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The stable insertion of a copy of their genome into the host cell genome is an essential step of the life cycle of retroviruses. The site of viral DNA integration, mediated by the viral-encoded integrase enzyme, has important consequences for both the virus and the host cell. The analysis of retroviral integration site distribution was facilitated by the availability of the human genome sequence, revealing the non-random feature of integration site selection and identifying different favored and disfavored genomic locations for individual retroviruses. This review will summarize the current knowledge about retroviral differences in their integration site preferences as well as the mechanisms involved in this process.
Keywords: retrovirus; integration; site selection; integrase; HIV; LEDGF; LEDGF/p75; PSIP1; lentivirus; transcription
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MDPI and ACS Style

Desfarges, S.; Ciuffi, A. Retroviral Integration Site Selection. Viruses 2010, 2, 111-130.

AMA Style

Desfarges S, Ciuffi A. Retroviral Integration Site Selection. Viruses. 2010; 2(1):111-130.

Chicago/Turabian Style

Desfarges, Sébastien; Ciuffi, Angela. 2010. "Retroviral Integration Site Selection." Viruses 2, no. 1: 111-130.


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