Special Issue "Chromatin Control of Viral Infection"
Deadline for manuscript submissions: 31 May 2013
Dr. Thomas M. Kristie
Chief, Molecular Genetics Section, LVD, NIAID, Building 33, Room 3W20B.7, 33 North Drive, MSC 3209, Bethesda, MD 20892-3209, USA
Interests: herpes simplex virus gene expression; transcriptional coactivators in herpesvirus lytic and latency reaction; chromatin control of herpesvirus lytic and latency-reaction cycles; mechanisms involved in RNAP II-mediated gene transcription
The role of chromatin and epigenetic regulation in cellular transcription, replication, repair, and development has been well recognized. However, invading viral pathogens that depend upon cellular nuclear machinery are also subject to the regulatory impacts of chromatin.
For lytic pathogens, successful infection depends upon the ability to counter cellular defense mechanisms such as deposition of repressive chromatin structures with the ability to utilize cellular chromatin modulation activities that promote the efficient utilization of cellular transcription and/or replication machinery. Additionally, viral pathogens whose complex replication cycles include coupled stages of lytic replication and latency/persistence are impacted epigenetic states that play controlling roles in determining the viral state.
Advances in understanding the basic biology of chromatin deposition, modification, and modulation/remodeling will contribute to the understanding of viral diseases and present novel opportunities for prophylaxis or treatment. The workshop "2012 Chromatin Control of Viral Infection" brings together leaders in this research area representing various viral families as well as select experts in general chromatin biology.
Dr. Thomas M. Kristie
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
Review: Deregulation of Epigenetic Mechanisms by the Hepatitis B Virus X Protein in Hepatocarcinogenesis
Viruses 2013, 5(3), 858-872; doi:10.3390/v5030858
Received: 4 February 2013; in revised form: 12 March 2013 / Accepted: 13 March 2013 / Published: 18 March 2013| Download PDF Full-text (233 KB) | Download XML Full-text
Review: The Role of the CoREST/REST Repressor Complex in Herpes Simplex Virus 1 Productive Infection and in Latency
Viruses 2013, 5(5), 1208-1218; doi:10.3390/v5051208
Received: 11 March 2013; in revised form: 21 April 2013 / Accepted: 23 April 2013 / Published: 29 April 2013| Download PDF Full-text (298 KB) | Download XML Full-text
Review: Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins
Viruses 2013, 5(5), 1231-1249; doi:10.3390/v5051231
Received: 10 April 2013; in revised form: 23 April 2013 / Accepted: 27 April 2013 / Published: 14 May 2013| Download PDF Full-text (446 KB) | Download XML Full-text
Review: The Dynamics of HCF-1 Modulation of Herpes Simplex Virus Chromatin during Initiation of Infection
Viruses 2013, 5(5), 1272-1291; doi:10.3390/v5051272 (doi registration under processing)
Received: 11 April 2013; in revised form: 14 May 2013 / Accepted: 14 May 2013 / Published: 22 May 2013| Download PDF Full-text (928 KB)
Last update: 15 April 2013