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Role of Polycomb Proteins in Regulating HSV-1 Latency
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Box 100266, Gainesville, FL 32610, USA
* Author to whom correspondence should be addressed.
Received: 29 May 2013; in revised form: 4 July 2013 / Accepted: 4 July 2013 / Published: 15 July 2013
Abstract: Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.
Keywords: HSV; herpes; PRC; Polycomb; heterochromatin; latency; reactivation
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Cite This Article
MDPI and ACS Style
Watson, Z.; Dhummakupt, A.; Messer, H.; Phelan, D.; Bloom, D. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses 2013, 5, 1740-1757.
Watson Z, Dhummakupt A, Messer H, Phelan D, Bloom D. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses. 2013; 5(7):1740-1757.
Watson, Zachary; Dhummakupt, Adit; Messer, Harald; Phelan, Dane; Bloom, David. 2013. "Role of Polycomb Proteins in Regulating HSV-1 Latency." Viruses 5, no. 7: 1740-1757.