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Viruses 2013, 5(6), 1571-1586; doi:10.3390/v5061571

Bromodomain Proteins in HIV Infection

1 Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA 2 Department of Medicine, University of California, San Francisco, CA 94158, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 13 May 2013 / Revised: 9 June 2013 / Accepted: 13 June 2013 / Published: 21 June 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
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Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.
Keywords: bromodomains; HIV; PCAF; PBAF; p300; CBP; TRIM28; BRD2; BRD4 bromodomains; HIV; PCAF; PBAF; p300; CBP; TRIM28; BRD2; BRD4
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Boehm, D.; Conrad, R.J.; Ott, M. Bromodomain Proteins in HIV Infection. Viruses 2013, 5, 1571-1586.

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