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Bromodomain Proteins in HIV Infection
Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
Department of Medicine, University of California, San Francisco, CA 94158, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 13 May 2013; in revised form: 9 June 2013 / Accepted: 13 June 2013 / Published: 21 June 2013
Abstract: Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.
Keywords: bromodomains; HIV; PCAF; PBAF; p300; CBP; TRIM28; BRD2; BRD4
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Cite This Article
MDPI and ACS Style
Boehm, D.; Conrad, R.J.; Ott, M. Bromodomain Proteins in HIV Infection. Viruses 2013, 5, 1571-1586.
Boehm D, Conrad RJ, Ott M. Bromodomain Proteins in HIV Infection. Viruses. 2013; 5(6):1571-1586.
Boehm, Daniela; Conrad, Ryan J.; Ott, Melanie. 2013. "Bromodomain Proteins in HIV Infection." Viruses 5, no. 6: 1571-1586.