Viruses 2013, 5(6), 1571-1586; doi:10.3390/v5061571

Bromodomain Proteins in HIV Infection

1,2,†email, 1,2,†email and 1,2,* email
1 Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA 2 Department of Medicine, University of California, San Francisco, CA 94158, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 13 May 2013; in revised form: 9 June 2013 / Accepted: 13 June 2013 / Published: 21 June 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
PDF Full-text Download PDF Full-Text [2056 KB, uploaded 21 June 2013 14:54 CEST]
Abstract: Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.
Keywords: bromodomains; HIV; PCAF; PBAF; p300; CBP; TRIM28; BRD2; BRD4

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Boehm, D.; Conrad, R.J.; Ott, M. Bromodomain Proteins in HIV Infection. Viruses 2013, 5, 1571-1586.

AMA Style

Boehm D, Conrad RJ, Ott M. Bromodomain Proteins in HIV Infection. Viruses. 2013; 5(6):1571-1586.

Chicago/Turabian Style

Boehm, Daniela; Conrad, Ryan J.; Ott, Melanie. 2013. "Bromodomain Proteins in HIV Infection." Viruses 5, no. 6: 1571-1586.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert