Open AccessThis article is
- freely available
Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins
Division of Infectious Diseases, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, 181 Longwood Avenue, MCP 861, Boston, MA 02115, USA
* Authors to whom correspondence should be addressed.
Received: 10 April 2013; in revised form: 23 April 2013 / Accepted: 27 April 2013 / Published: 14 May 2013
Abstract: The role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic tumor suppressor pathway that thwarts expansion of cells that have suffered oncogenic hits. Infections with human cancer viruses including human papillomaviruses (HPVs) and Epstein-Barr virus can trigger oncogene-induced senescence, and the viruses have evolved strategies to abrogate this response in order to establish an infection and reprogram their host cells to establish a long-term persistent infection. As a consequence of inhibiting polycomb repression and evading oncogene induced-senescence, HPV infected cells have an altered epigenetic program as evidenced by aberrant homeobox gene expression. Similar alterations are frequently observed in non-virus associated human cancers and may be harnessed for diagnosis and therapy.
Keywords: cervical cancer; biomarker; histone methylation; tumor suppressor
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
McLaughlin-Drubin, M.E.; Munger, K. Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins. Viruses 2013, 5, 1231-1249.
McLaughlin-Drubin ME, Munger K. Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins. Viruses. 2013; 5(5):1231-1249.
McLaughlin-Drubin, Margaret E.; Munger, Karl. 2013. "Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins." Viruses 5, no. 5: 1231-1249.