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Viruses 2013, 5(6), 1374-1394; doi:10.3390/v5061374
Review

Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

*  and
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
* Author to whom correspondence should be addressed.
Received: 2 April 2013 / Revised: 21 May 2013 / Accepted: 21 May 2013 / Published: 30 May 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
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Abstract

The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.
Keywords: Brd4; BET protein; HPV; papillomavirus; transcription; chromatin; replication; tethering; partitioning; bromodomain Brd4; BET protein; HPV; papillomavirus; transcription; chromatin; replication; tethering; partitioning; bromodomain
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

McBride, A.A.; Jang, M.K. Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle. Viruses 2013, 5, 1374-1394.

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