Next Article in Journal
Norovirus Contamination Levels in Ground Water Treatment Systems Used for Food-Catering Facilities in South Korea
Next Article in Special Issue
Role of Polycomb Proteins in Regulating HSV-1 Latency
Previous Article in Journal / Special Issue
Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense
Viruses 2013, 5(7), 1633-1645; doi:10.3390/v5071633
Review

Chromatin, Non-Coding RNAs, and the Expression of HIV

1
 and 1,2,*
Received: 3 April 2013; in revised form: 21 June 2013 / Accepted: 21 June 2013 / Published: 28 June 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
View Full-Text   |   Download PDF [2196 KB, uploaded 28 June 2013]   |   Browse Figure
Abstract: HIV is a chronic viral infection affecting an estimated 34 million people worldwide. Current therapies employ the use of a cocktail of antiretroviral medications to reduce the spread and effects of HIV, however complete eradication from an individual currently remains unattainable. Viral latency and regulation of gene expression is a key consideration when developing effective treatments. While our understanding of these processes remains incomplete new developments suggest that non-coding RNA (ncRNA) mediated regulation may provide an avenue to controlling both viral expression and latency. Here we discuss the importance of known regulatory mechanisms and suggest directions for further study, in particular the use ncRNAs in controlling HIV expression.
Keywords: HIV; non-coding RNA; chromatin remodeling; latency; reactivation HIV; non-coding RNA; chromatin remodeling; latency; reactivation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Groen, J.N.; Morris, K.V. Chromatin, Non-Coding RNAs, and the Expression of HIV. Viruses 2013, 5, 1633-1645.

AMA Style

Groen JN, Morris KV. Chromatin, Non-Coding RNAs, and the Expression of HIV. Viruses. 2013; 5(7):1633-1645.

Chicago/Turabian Style

Groen, Jessica N.; Morris, Kevin V. 2013. "Chromatin, Non-Coding RNAs, and the Expression of HIV." Viruses 5, no. 7: 1633-1645.


Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert