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Chromatin, Non-Coding RNAs, and the Expression of HIV
School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
* Author to whom correspondence should be addressed.
Received: 3 April 2013; in revised form: 21 June 2013 / Accepted: 21 June 2013 / Published: 28 June 2013
Abstract: HIV is a chronic viral infection affecting an estimated 34 million people worldwide. Current therapies employ the use of a cocktail of antiretroviral medications to reduce the spread and effects of HIV, however complete eradication from an individual currently remains unattainable. Viral latency and regulation of gene expression is a key consideration when developing effective treatments. While our understanding of these processes remains incomplete new developments suggest that non-coding RNA (ncRNA) mediated regulation may provide an avenue to controlling both viral expression and latency. Here we discuss the importance of known regulatory mechanisms and suggest directions for further study, in particular the use ncRNAs in controlling HIV expression.
Keywords: HIV; non-coding RNA; chromatin remodeling; latency; reactivation
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MDPI and ACS Style
Groen, J.N.; Morris, K.V. Chromatin, Non-Coding RNAs, and the Expression of HIV. Viruses 2013, 5, 1633-1645.
Groen JN, Morris KV. Chromatin, Non-Coding RNAs, and the Expression of HIV. Viruses. 2013; 5(7):1633-1645.
Groen, Jessica N.; Morris, Kevin V. 2013. "Chromatin, Non-Coding RNAs, and the Expression of HIV." Viruses 5, no. 7: 1633-1645.