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Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
* Author to whom correspondence should be addressed.
Received: 14 May 2013; in revised form: 17 June 2013 / Accepted: 18 June 2013 / Published: 27 June 2013
Abstract: Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based “omic” technologies to infectious disease research, offering a systems biology view of infection.
Keywords: herpesvirus; HDAC; IFI16; acetylation; NF-κB; p53; proteomics; metabolomics; chemoproteomics
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Cite This Article
MDPI and ACS Style
Guise, A.J.; Budayeva, H.G.; Diner, B.A.; Cristea, I.M. Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense. Viruses 2013, 5, 1607-1632.
Guise AJ, Budayeva HG, Diner BA, Cristea IM. Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense. Viruses. 2013; 5(7):1607-1632.
Guise, Amanda J.; Budayeva, Hanna G.; Diner, Benjamin A.; Cristea, Ileana M. 2013. "Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense." Viruses 5, no. 7: 1607-1632.