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Viruses 2013, 5(7), 1607-1632; doi:10.3390/v5071607

Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense

Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
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Received: 14 May 2013 / Revised: 17 June 2013 / Accepted: 18 June 2013 / Published: 27 June 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
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Abstract

Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based “omic” technologies to infectious disease research, offering a systems biology view of infection. View Full-Text
Keywords: herpesvirus; HDAC; IFI16; acetylation; NF-κB; p53; proteomics; metabolomics; chemoproteomics herpesvirus; HDAC; IFI16; acetylation; NF-κB; p53; proteomics; metabolomics; chemoproteomics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Guise, A.J.; Budayeva, H.G.; Diner, B.A.; Cristea, I.M. Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense. Viruses 2013, 5, 1607-1632.

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