Special Issue "Synthesis of Nucleosides, Nucleotides and Their Derivatives"
Deadline for manuscript submissions: closed (31 August 2013)
Prof. Dr. Carlo Siciliano
Department of Pharmacy, Health and Nutritional Sciences, Via Pietro Bucci, Edificio Polifunzionale, I-87036 Arcavacata di Rende (CS), Italy
Interests: biomolecules and their non-natural analogues; modified nucleosides and nucleotides; non-natural and non-proteogenic amino acids; modified peptides; protease inhibitors; peptide biosensors; modified steroids as new molecular probes in newborn pathologies; self-assembling; solid-phase peptide synthesis; 1D- and 2D-High Resolution NMR techniques in molecular structure characterization; High Resolution NMR techniques in food analysis and natural matrices control
Nucleosides, nucleotides and their synthetic analogues have been proposed for the diagnostic control and the therapeutic treatment of different kinds of grave pathologies which are related to viral infections and to many types of cancer. The history of these classes of compounds is certainly characterized by their wide biological and pharmaceutical potentialities, while a critical and key role has been played by the plethora of synthetic methodologies developed, time by time, for the preparation on non-natural analogues. A good number of compounds featuring modified heterocycles as nucleobases and/or sugar moieties, and phosphorylated frames showing high similarities with respect to those found in natural congeners, are now available. The scope of this Special Issue is to collect the most recent acquisitions and state of the art concerning chemical procedures used in the design and structural characterization of nucleosides, nucleotides and their modified analogues, corroborated by the results obtained from biological tests. This Special Issue will focus on all aspects regarding the description of new synthetic approaches and methodologies which can usefully be applied to modification of nucleobases, sugar moieties and phosphodiester linkages. Research papers and reviews dealing with the presented fields are welcome for the preparation of this Special Issue of Molecules.
Prof. Dr. Carlo Siciliano
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- modified analogues
- nucleobases modification
- sugar moiety modification
- phosphorylation methods
- nucleic acid building blocks
- biological activity
- anticancer action
- antiviral action
- enzyme Inhibition
- diagnostic potentialities