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Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
INSERM U869, Bordeaux, F-33076, France
Université de Bordeaux, Bordeaux, F-33076, France
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 28 August 2013; in revised form: 25 September 2013 / Accepted: 25 September 2013 / Published: 30 September 2013
Abstract: Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower glim) compared to the first generation of GNFs.
Keywords: nucleolipid; nucleoside; glycosyl; fluorocarbon; amphiphiles; surface tension
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Latxague, L.; Patwa, A.; Amigues, E.; Barthélémy, P. Glycosyl-Nucleolipids as New Bioinspired Amphiphiles. Molecules 2013, 18, 12241-12263.
Latxague L, Patwa A, Amigues E, Barthélémy P. Glycosyl-Nucleolipids as New Bioinspired Amphiphiles. Molecules. 2013; 18(10):12241-12263.
Latxague, Laurent; Patwa, Amit; Amigues, Eric; Barthélémy, Philippe. 2013. "Glycosyl-Nucleolipids as New Bioinspired Amphiphiles." Molecules 18, no. 10: 12241-12263.