Molecules 2013, 18(10), 12241-12263; doi:10.3390/molecules181012241
Article

Glycosyl-Nucleolipids as New Bioinspired Amphiphiles

1,2,†, 1,2,†, 1,2 and 1,2,* email
Received: 28 August 2013; in revised form: 25 September 2013 / Accepted: 25 September 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower glim) compared to the first generation of GNFs.
Keywords: nucleolipid; nucleoside; glycosyl; fluorocarbon; amphiphiles; surface tension
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MDPI and ACS Style

Latxague, L.; Patwa, A.; Amigues, E.; Barthélémy, P. Glycosyl-Nucleolipids as New Bioinspired Amphiphiles. Molecules 2013, 18, 12241-12263.

AMA Style

Latxague L, Patwa A, Amigues E, Barthélémy P. Glycosyl-Nucleolipids as New Bioinspired Amphiphiles. Molecules. 2013; 18(10):12241-12263.

Chicago/Turabian Style

Latxague, Laurent; Patwa, Amit; Amigues, Eric; Barthélémy, Philippe. 2013. "Glycosyl-Nucleolipids as New Bioinspired Amphiphiles." Molecules 18, no. 10: 12241-12263.

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