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Molecules 2013, 18(11), 13654-13665; doi:10.3390/molecules181113654
Article

Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer

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2
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1,*  and 1,*
Received: 26 August 2013 / Revised: 14 October 2013 / Accepted: 23 October 2013 / Published: 5 November 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
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Abstract

The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.
Keywords: Stille coupling; nucleosides; oligonucleotides; methyl transfer; Positron Emission Tomography Stille coupling; nucleosides; oligonucleotides; methyl transfer; Positron Emission Tomography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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James, D.; Escudier, J.-M.; Szlosek-Pinaud, M.; Fouquet, E. Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer. Molecules 2013, 18, 13654-13665.

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