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Molecules 2013, 18(10), 12966-12976; doi:10.3390/molecules181012966

Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt

, , , *  and *
Modified Nucleic Acids, Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (UMR 5068) Université de Toulouse (Université Paul Sabatier), Cedex 9, 31062 Toulouse, France
* Authors to whom correspondence should be addressed.
Received: 28 August 2013 / Revised: 30 September 2013 / Accepted: 9 October 2013 / Published: 17 October 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
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Two fluorescent streptocyanine labelled oligonucleotides have been synthesized by a simple “click” reaction between a non-fluorescent hemicarboxonium salt and aminoalkyl functionalized thymidines within the oligonucleotide and their spectrophotometric properties have been studied.
Keywords: nucleotides; modified analogues; diagnostic potentialities nucleotides; modified analogues; diagnostic potentialities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Maether, M.-P.; Lapin, K.; Muntean, A.; Payrastre, C.; Escudier, J.-M. Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt. Molecules 2013, 18, 12966-12976.

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