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Molecules 2013, 18(10), 12966-12976; doi:10.3390/molecules181012966

Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt

, , , *  and *
Modified Nucleic Acids, Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (UMR 5068) Université de Toulouse (Université Paul Sabatier), Cedex 9, 31062 Toulouse, France
* Authors to whom correspondence should be addressed.
Received: 28 August 2013 / Revised: 30 September 2013 / Accepted: 9 October 2013 / Published: 17 October 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
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Two fluorescent streptocyanine labelled oligonucleotides have been synthesized by a simple “click” reaction between a non-fluorescent hemicarboxonium salt and aminoalkyl functionalized thymidines within the oligonucleotide and their spectrophotometric properties have been studied.
Keywords: nucleotides; modified analogues; diagnostic potentialities nucleotides; modified analogues; diagnostic potentialities
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Maether, M.-P.; Lapin, K.; Muntean, A.; Payrastre, C.; Escudier, J.-M. Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt. Molecules 2013, 18, 12966-12976.

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