Special Issue "Synthesis of Bioactive Compounds from the Chiral Pool"
Deadline for manuscript submissions: closed (15 June 2016)
Prof. Dr. Carlo Siciliano
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, I-87036 Arcavacata di Rende, Italy
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Interests: synthesis of biomolecules and their analogues; amino acid and peptide chemistry; modification of natural amino acids; chiral templates; design and synthesis of protease inhibitors; steroid chemistry
Chiral pool synthesis is a well-known and widespread approach for the design and preparation of chiral compounds of biological and pharmacological interest. This particularly important and versatile strategy employs, as starting materials, simple and complex enantiopure compounds readily available from the arsenal of natural sources. The most common components of the chiral pool are monosaccharides and amino acids. The use of these cheap starting materials is of great importance and helpful if the synthetic target compounds display strong similarities to the structure of the enantiopure natural precursors. Moreover, the use of the chiral pool is especially noticeable and fruitful when meandering multistep approaches to enantiopure bioactive compounds may be required. The strategy based on natural sources of chiral compounds is also of great aid in all cases of synthetic procedures characterized by considerable losses in total yields, and when suitable enantiopure scaffolds may be difficult to achieve. The aim of this Special Issue is to gather an inspiring anthology for the dissemination of the most recent acquisitions in the field of design, preparation, and characterization of enantiopure compounds starting from the chiral pool. Reviews, feature articles, and original research papers that focus on new divergent and convergent total syntheses of bioactive natural compounds and their analogues starting from the chiral pool are all welcomed.
Prof. Dr. Carlo Siciliano
Dr. Constantinos M. Athanassopoulos
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- asymmetric synthesis
- enantiopure chiral templates
- total synthesis
- bioactive compounds