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Molecules 2013, 18(10), 12740-12750; doi:10.3390/molecules181012740
Article

An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)

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Received: 2 September 2013 / Revised: 2 October 2013 / Accepted: 9 October 2013 / Published: 15 October 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
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Abstract

An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucleosides were brominated in moderate to high yields following this procedure.
Keywords: bromination; sodium monobromoisocyanurate (SMBI); pyridine-based nucleosides; purine-based nucleosides; bromonucleosides bromination; sodium monobromoisocyanurate (SMBI); pyridine-based nucleosides; purine-based nucleosides; bromonucleosides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Maity, J.; Stromberg, R. An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI). Molecules 2013, 18, 12740-12750.

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