Special Issue "Improvements for Resveratrol Efficacy"
Deadline for manuscript submissions: closed (28 February 2017)
Prof. Dr. Norbert Latruffe
Université de Bourgogne, 21000 Dijon, France
Website | E-Mail
Interests: bio-active polyphenols; resveratrol; inflammation; bio-availability; cancer; pathologies prevention
Norbert Latruffe obtained his PhD 1977, and has been appointed in 1989 full Professor in Biochemistry at the University of Burgundy-Dijon France, and as head of the Laboratory of Molecular and Cellular Biology to 2006. Then, he was in charge of the team of Biochemistry of Metabolism and Nutrition in the INSERM research center, UMR 866 of Dijon until end of 2011. Since 2013 he is senior Professor at the laboratory of Biochemistry at the faculty of life science. In 1998 he launched a new challenge on the preventing role of vine polyphenols especially resveratrol, against age-related pathologies: cancer, inflammation cardiovascular. He was one of the first to explore resveratrol transport and metabolism (2004), its pro-apoptotic properties (2004), discovered a new resveratrol signalling pathway through micro RNA’s modulation (2010). In 2014 he showed a preventive effect of wine polyphenols towards colon cancer in mice model. He organized several and workshop on wine and health. Recently he served as editor or co-editor of «Molecules» two special issues: Natural products and inflammation (2016) and Improvement of resveratrol efficacy (2017). To date, he published near 170 international papers and has given more than invited 140 lectures. In 2017 he conducted the edition of a book deal on wine and mediterranean diet (EUD editor, Dijon). N. Latruffe is (or past) expert of several evaluation councils and is member of the orientation council of the prestigious UNESCO Chair «heritage and traditions of wine ». He also awarded several distinctions.
Dr. Dominique Vervandier-Fasseur
Resveratrol is a well-known phenolic stilbene because of its presence in several edible plants and its proposed beneficial properties in human health. However, resveratrol is not a “magical bullet” which we might expect in medicine because of delivery problems in humans, at least in part due to its weak bioavailability. Thus, it is essential to look forward and to use recent knowledge and different innovating aspects of development of this multi-targeted natural molecule in attempts to enhance its use for promoting human health food and medicinal preparations. Several exploratory methods can be considered, starting with unexpected natural and original synthetic analogues of resveratrol in which structural modifications can increase and strengthen biological activities. Liposomal formulation or encapsulation in cyclodextrins of bio-active molecules can hopefully improve their specific delivery; these biotechnological aspects can be applied in the case of resveratrol. Advances of analytical techniques afford an enhanced tracking of resveratrol and its metabolites in the cellular environment and body, which implies a better understanding of the biochemical mechanisms, and, therefore, can provide a basis for new technological achievements. The results of these innovative analyses will provide further knowledge to define a more optimal stilbenoid structure and more optimal delivery systems.
Reviews and original research papers about the developments in the resveratrol actions among the pre-cited fields are all welcome in the aim of improving the bioavailability and delivery of resveratrol in human, especially in the following topics:
- new biotechnological applications for improvements in health, food science and agronomy,
- knowledge of resveratrol translocation mechanism across the brain blood barrier (BBB) for possible application in neurodegenerative diseases.
- natural derivatives and new synthetic analogues of resveratrol strengthening biological activities
- advances of analytical techniques for an enhanced tracking of resveratrol and its metabolites in cellular environment.
- new and old cellular and tissue targets for resveratrol and derivatives
- any technological improvements for resveratrol efficacy
Prof. Norbert Latruffe
Dr. Ole Vang
Dr. Dominique Vervandier-Fasseur
Manuscript Submission Information
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- metabolism and bioavailability
- natural and synthetic derivatives of resveratrol
- biochemical mechanisms
- cellular and organ targets of resveratrol and derivatives
- analytical techniques