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Molecules 2017, 22(8), 1329; doi:10.3390/molecules22081329

Significance of Resveratrol in Clinical Management of Chronic Diseases

School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
Institute of Automation, Chinese Academy of Sciences, Beijing 100029, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 17 July 2017 / Revised: 4 August 2017 / Accepted: 9 August 2017 / Published: 18 August 2017
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
View Full-Text   |   Download PDF [986 KB, uploaded 18 August 2017]   |  


Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases. View Full-Text
Keywords: pre-clinical studies; clinical studies; absorption; toxicity; diabetes mellitus; obesity; cardiovascular diseases; cancer; aging pre-clinical studies; clinical studies; absorption; toxicity; diabetes mellitus; obesity; cardiovascular diseases; cancer; aging

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wahab, A.; Gao, K.; Jia, C.; Zhang, F.; Tian, G.; Murtaza, G.; Chen, J. Significance of Resveratrol in Clinical Management of Chronic Diseases. Molecules 2017, 22, 1329.

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