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Molecules 2017, 22(5), 847; doi:10.3390/molecules22050847

Functional Mitochondria Are Important for the Effect of Resveratrol

Department of Science and Environment, Roskilde University, Roskilde DK-4000, Denmark
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Academic Editor: Derek J. McPhee
Received: 13 March 2017 / Revised: 15 May 2017 / Accepted: 16 May 2017 / Published: 20 May 2017
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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Abstract

Resveratrol (Resv) is a polyphenol reported to modulate mitochondrial activity. The aim was to use HeLa and 143B cells to characterize the action of Resv on mitochondrial activity, cell size and proliferation using wild type (WT) and Rho 0 cells deficient in mitochondrial DNA. In both HeLa WT and Rho 0 cells, the oxygen consumption rate (OCR) was increased at 20 µM Resv after 24 h, whereas only a non-significant increase of OCR was observed in 143B WT cells. Resv decreased cell number concentration-dependently in both WT and Rho 0 cell types. An increased cell diameter was observed in HeLa WT, but not in Rho 0 when treated with Resv. Overall, the findings presented indicate that functional mitochondria are a prerequisite for cell enlargement by Resv. View Full-Text
Keywords: mitochondria; resveratrol; HeLa; 143B; wild type; Rho 0; oxygen consumption rate; oxidative stress mitochondria; resveratrol; HeLa; 143B; wild type; Rho 0; oxygen consumption rate; oxidative stress
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Widlund, A.L.; Baral, K.; Dalgaard, L.T.; Vang, O. Functional Mitochondria Are Important for the Effect of Resveratrol. Molecules 2017, 22, 847.

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