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Molecules 2017, 22(6), 1014; doi:10.3390/molecules22061014

Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target

1
Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 20550-013, Brazil
2
Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
3
Instituto de Bioquímica Médica Leopoldo de Meis & Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editors: Norbert Latruffe, Ole Vang and Dominique Vervandier-Fasseur
Received: 20 May 2017 / Revised: 11 June 2017 / Accepted: 14 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
View Full-Text   |   Download PDF [3073 KB, uploaded 18 June 2017]   |  

Abstract

Increasing epidemiological and experimental evidence has demonstrated an inverse relationship between the consumption of plant foods and the incidence of chronic diseases, including cancer. Microcomponents that are naturally present in such foods, especially polyphenols, are responsible for the benefits to human health. Resveratrol is a diet-derived cancer chemopreventive agent with high therapeutic potential, as demonstrated by different authors. The aim of this review is to collect and present recent evidence from the literature regarding resveratrol and its effects on cancer prevention, molecular signaling (especially regarding the involvement of p53 protein), and therapeutic perspectives with an emphasis on clinical trial results to date. View Full-Text
Keywords: resveratrol; cancer; signal transduction; p53; clinical trials resveratrol; cancer; signal transduction; p53; clinical trials
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ferraz da Costa, D.C.; Fialho, E.; Silva, J.L. Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target. Molecules 2017, 22, 1014.

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