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Molecules 2017, 22(1), 137; doi:10.3390/molecules22010137

Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology

1
School of Pharmacy, Concordia University Wisconsin, 12800 N. Lake Shore Drive, Mequon, WI 53097, USA
2
School of Pharmacy, Medical College of Wisconsin, Milwaukee, 8701 W. Watertown Plank Road, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Norbert Latruffe
Received: 16 November 2016 / Revised: 24 December 2016 / Accepted: 9 January 2017 / Published: 14 January 2017
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
View Full-Text   |   Download PDF [2866 KB, uploaded 14 January 2017]   |  

Abstract

Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol. A dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement, stability in solution and cream dosage forms. We have also developed a high performance liquid chromatography method to measure the resveratrol within the final product. PAMAM dendrimers increased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore, this product would be water based ‘green’ formulation devoid of harsh organic solvents and oils and can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to increase overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation was successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation in anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex could also be added to other product forms for additional purposes and applications. View Full-Text
Keywords: resveratrol; dendrimer; PAMAM; solubility; stability; transdermal; topical; cream; antiaging; safe resveratrol; dendrimer; PAMAM; solubility; stability; transdermal; topical; cream; antiaging; safe
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pentek, T.; Newenhouse, E.; O’Brien, B.; Chauhan, A.S. Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology. Molecules 2017, 22, 137.

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