Special Issue "Catalytic Nucleic Acids"

Quicklinks

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 May 2010)

Special Issue Editor

Guest Editor
Dr. Lun-Quan Sun
Department of Molecular and Medical Biology, University of Technology Sydney, Australia
E-Mail: lun-quan.sun@uts.edu.au
Interests: anti-viral and anti-cancer gene therapy;-development of nucleic acid-based drugs; functional genomics; assay development and drug screening; disease models and their biology

Special Issue Information

Dear Colleagues,

The past decades have seen the rapid evolution of gene-silencing strategies based on catalytic nucleic acids. Since the discovery of self-cleavage and ligation activity of the group I intron, the expansion of research interest in catalytic nucleic acids has provided a valuable nonprotein resource for manipulating biomolecules. RNA-cleaving RNA enzymes or “ribozymes” hold center stage because of their tremendous potential for mediating gene inactivation. Recently a new class of catalytic nucleic acid made entirely of DNA has emerged through in vitro selection. DNA enzymes or deoxyribozyme with extraordinary RNA cleavage activity has already demonstrated their capacity for gene suppression both in vitro and in vivo. These new molecules, although rivaling the activity and stability of synthetic ribozymes, are limited equally by inefficient delivery to the intracellular target RNA. The challenge of in vivo delivery is being addressed with the assessment of a variety of approaches in animal models with the aim of bringing these compounds closer to the clinic.

Dr. Lun-Quan Sun
Guest Editor

Keywords

  • ribozyme
  • DNAzyme
  • deoxyribozyme
  • in vitro selection
  • gene silencing
  • chemical modifications
  • catalytic nucleic acids
  • oligonucleotide delivery

Published Papers (10 papers)

Download All Papers
Sort by:
Display options:
Select articles Export citation of selected articles as:
Select/unselect all
Displaying article 1-10
p. 7197-7207
by , , , ,  and
Molecules 2010, 15(10), 7197-7207; doi:10.3390/molecules15107197
Received: 1 September 2010; Accepted: 15 September 2010 / Published: 18 October 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (682 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
p. 6269-6284
by  and
Molecules 2010, 15(9), 6269-6284; doi:10.3390/molecules15096269
Received: 30 June 2010; in revised form: 23 August 2010 / Accepted: 2 September 2010 / Published: 6 September 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (1373 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
p. 6127-6139
by , , ,  and
Molecules 2010, 15(9), 6127-6139; doi:10.3390/molecules15096127
Received: 18 June 2010; in revised form: 26 August 2010 / Accepted: 30 August 2010 / Published: 1 September 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (537 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
p. 5850-5865
by , ,  and
Molecules 2010, 15(9), 5850-5865; doi:10.3390/molecules15095850
Received: 29 June 2010; in revised form: 12 August 2010 / Accepted: 18 August 2010 / Published: 26 August 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (541 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
abstract graphic
p. 5423-5444
by  and
Molecules 2010, 15(8), 5423-5444; doi:10.3390/molecules15085423
Received: 18 June 2010; in revised form: 14 July 2010 / Accepted: 6 August 2010 / Published: 9 August 2010
Show/Hide Abstract | Cited by 19 | PDF Full-text (856 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
p. 5460-5472
by ,  and
Molecules 2010, 15(8), 5460-5472; doi:10.3390/molecules15085460
Received: 18 June 2010; in revised form: 3 August 2010 / Accepted: 5 August 2010 / Published: 9 August 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (113 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
p. 5389-5407
by
Molecules 2010, 15(8), 5389-5407; doi:10.3390/molecules15085389
Received: 1 June 2010; in revised form: 29 July 2010 / Accepted: 4 August 2010 / Published: 6 August 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (591 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
abstract graphic
p. 4757-4772
by , ,  and
Molecules 2010, 15(7), 4757-4772; doi:10.3390/molecules15074757
Received: 31 May 2010; in revised form: 28 June 2010 / Accepted: 1 July 2010 / Published: 7 July 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (616 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
abstract graphic
p. 4670-4678
by ,  and
Molecules 2010, 15(7), 4670-4678; doi:10.3390/molecules15074670
Received: 8 June 2010; in revised form: 28 June 2010 / Accepted: 29 June 2010 / Published: 30 June 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (234 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
p. 4610-4638
by , , ,  and
Molecules 2010, 15(7), 4610-4638; doi:10.3390/molecules15074610
Received: 26 May 2010; in revised form: 17 June 2010 / Accepted: 24 June 2010 / Published: 28 June 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (695 KB)
(This article belongs to the Special Issue Catalytic Nucleic Acids)
abstract graphic
Select/unselect all
Displaying article 1-10
Select articles Export citation of selected articles as:

Last update: 4 March 2014

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert