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Molecules 2010, 15(8), 5460-5472; doi:10.3390/molecules15085460

The Application of Ribozymes and DNAzymes in Muscle and Brain

1, 2 and 1,*
Received: 18 June 2010 / Revised: 3 August 2010 / Accepted: 5 August 2010 / Published: 9 August 2010
(This article belongs to the Special Issue Catalytic Nucleic Acids)
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Abstract: The discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated diseases through down regulation or modulation of endogenous gene expression involved in these ailments. These CNAs aim either towards the elimination or repair of pathological gene expression. Ribozymes, a class of CNAs, can be mostly used to down-regulate (by RNA cleavage) or repair (by RNA trans-splicing) unwanted gene expression involved in disease. DNAzymes, derived by in vitro selection processes are also able to bind and cleave RNA targets and therefore down-regulate gene expression. The purpose of this review is to present and discuss several applications of ribozymes and DNAzymes in muscle and brain. There are several diseases which affect muscle and brain and catalytic nucleic acids have been used as tools to target specific cellular transcripts involved in these groups of diseases.
Keywords: catalytic nucleic acids; ribozyme; DNAzyme; brain; muscle catalytic nucleic acids; ribozyme; DNAzyme; brain; muscle
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mastroyiannopoulos, N.P.; Uney, J.B.; Phylactou, L.A. The Application of Ribozymes and DNAzymes in Muscle and Brain. Molecules 2010, 15, 5460-5472.

AMA Style

Mastroyiannopoulos NP, Uney JB, Phylactou LA. The Application of Ribozymes and DNAzymes in Muscle and Brain. Molecules. 2010; 15(8):5460-5472.

Chicago/Turabian Style

Mastroyiannopoulos, Nikolaos P.; Uney, James B.; Phylactou, Leonidas A. 2010. "The Application of Ribozymes and DNAzymes in Muscle and Brain." Molecules 15, no. 8: 5460-5472.

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