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Int. J. Mol. Sci. 2011, 12(12), 8661-8694; doi:10.3390/ijms12128661
Review

A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms

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Received: 9 August 2011; in revised form: 7 November 2011 / Accepted: 10 November 2011 / Published: 30 November 2011
(This article belongs to the Special Issue Non-Coding RNAs)
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Abstract: Epigenetic mechanisms are responsible for the regulation of transcription of imprinted genes and those that induce a totipotent state. Starting just after fertilization, DNA methylation pattern undergoes establishment, reestablishment and maintenance. These modifications are important for normal embryo and placental developments. Throughout life and passing to the next generation, epigenetic events establish, maintain, erase and reestablish. In the context of differentiated cell reprogramming, demethylation and activation of genes whose expressions contribute to the pluripotent state is the crux of the matter. In this review, firstly, regulatory epigenetic mechanisms related to somatic cell nuclear transfer (SCNT) reprogramming are discussed, followed by embryonic development, and placental epigenetic issues.
Keywords: epigenetic; pluripotency; SCNT; embryogenesis; gametogenesis; polycomb; methylation; histone modification epigenetic; pluripotency; SCNT; embryogenesis; gametogenesis; polycomb; methylation; histone modification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Golbabapour, S.; Abdulla, M.A.; Hajrezaei, M. A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms. Int. J. Mol. Sci. 2011, 12, 8661-8694.

AMA Style

Golbabapour S, Abdulla MA, Hajrezaei M. A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms. International Journal of Molecular Sciences. 2011; 12(12):8661-8694.

Chicago/Turabian Style

Golbabapour, Shahram; Abdulla, Mahmood Ameen; Hajrezaei, Maryam. 2011. "A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms." Int. J. Mol. Sci. 12, no. 12: 8661-8694.


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