Int. J. Mol. Sci. 2013, 14(1), 1278-1292; doi:10.3390/ijms14011278
Review

ANRIL: Molecular Mechanisms and Implications in Human Health

Ada Congrainsemail, Kei Kamide* email, Mitsuru Ohishiemail and Hiromi Rakugiemail
Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 B6, Yamadaoka, Suita, Osaka 565-0871, Japan
* Author to whom correspondence should be addressed.
Received: 6 November 2012; in revised form: 28 December 2012 / Accepted: 4 January 2013 / Published: 10 January 2013
(This article belongs to the Special Issue Non-Coding RNAs)
PDF Full-text Download PDF Full-Text [448 KB, Updated Version, uploaded 24 January 2013 09:15 CET]
The original version is still available [428 KB, uploaded 10 January 2013 10:00 CET]
Abstract: ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. ANRIL has been shown to regulate its neighbor tumor suppressors CDKN2A/B by epigenetic mechanisms and thereby regulate cell proliferation and senescence. However, the clear role of ANRIL in the pathogenesis of these conditions is yet to be understood. Here, we review the recent findings on ANRIL molecular characterization and function, with a particular focus on its implications in human disease.
Keywords: ANRIL; CDKN2BAS; polycomb proteins; 9p21

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Congrains, A.; Kamide, K.; Ohishi, M.; Rakugi, H. ANRIL: Molecular Mechanisms and Implications in Human Health. Int. J. Mol. Sci. 2013, 14, 1278-1292.

AMA Style

Congrains A, Kamide K, Ohishi M, Rakugi H. ANRIL: Molecular Mechanisms and Implications in Human Health. International Journal of Molecular Sciences. 2013; 14(1):1278-1292.

Chicago/Turabian Style

Congrains, Ada; Kamide, Kei; Ohishi, Mitsuru; Rakugi, Hiromi. 2013. "ANRIL: Molecular Mechanisms and Implications in Human Health." Int. J. Mol. Sci. 14, no. 1: 1278-1292.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert