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Int. J. Mol. Sci. 2011, 12(8), 5070-5079; doi:10.3390/ijms12085070

Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes

1
Institute of Medical Microbiology, Justus-Liebig-University, Frankfurter Strasse 107, Giessen 35392, Germany
2
Department of Internal Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Received: 28 June 2011 / Revised: 15 July 2011 / Accepted: 8 August 2011 / Published: 10 August 2011
(This article belongs to the Special Issue Non-Coding RNAs)
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Abstract

Bacterial regulatory non-coding RNAs control numerous mRNA targets that direct a plethora of biological processes, such as the adaption to environmental changes, growth and virulence. Recently developed high-throughput techniques, such as genomic tiling arrays and RNA-Seq have allowed investigating prokaryotic cis- and trans-acting regulatory RNAs, including sRNAs, asRNAs, untranslated regions (UTR) and riboswitches. As a result, we obtained a more comprehensive view on the complexity and plasticity of the prokaryotic genome biology. Listeria monocytogenes was utilized as a model system for intracellular pathogenic bacteria in several studies, which revealed the presence of about 180 regulatory RNAs in the listerial genome. A regulatory role of non-coding RNAs in survival, virulence and adaptation mechanisms of L. monocytogenes was confirmed in subsequent experiments, thus, providing insight into a multifaceted modulatory function of RNA/mRNA interference. In this review, we discuss the identification of regulatory RNAs by high-throughput techniques and in their functional role in L. monocytogenes. View Full-Text
Keywords: Listeria monocytogenes; sRNA; asRNA; riboswitch; non-coding RNA; regulatory RNA; RNA-Seq; whole genome tiling arrays; infection; UTR Listeria monocytogenes; sRNA; asRNA; riboswitch; non-coding RNA; regulatory RNA; RNA-Seq; whole genome tiling arrays; infection; UTR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Izar, B.; Mraheil, M.A.; Hain, T. Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes. Int. J. Mol. Sci. 2011, 12, 5070-5079.

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