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Int. J. Mol. Sci. 2011, 12(8), 5070-5079; doi:10.3390/ijms12085070
Review

Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes

1,2
, 1
 and 1,*
1 Institute of Medical Microbiology, Justus-Liebig-University, Frankfurter Strasse 107, Giessen 35392, Germany 2 Department of Internal Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02118, USA
* Author to whom correspondence should be addressed.
Received: 28 June 2011 / Revised: 15 July 2011 / Accepted: 8 August 2011 / Published: 10 August 2011
(This article belongs to the Special Issue Non-Coding RNAs)
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Abstract

Bacterial regulatory non-coding RNAs control numerous mRNA targets that direct a plethora of biological processes, such as the adaption to environmental changes, growth and virulence. Recently developed high-throughput techniques, such as genomic tiling arrays and RNA-Seq have allowed investigating prokaryotic cis- and trans-acting regulatory RNAs, including sRNAs, asRNAs, untranslated regions (UTR) and riboswitches. As a result, we obtained a more comprehensive view on the complexity and plasticity of the prokaryotic genome biology. Listeria monocytogenes was utilized as a model system for intracellular pathogenic bacteria in several studies, which revealed the presence of about 180 regulatory RNAs in the listerial genome. A regulatory role of non-coding RNAs in survival, virulence and adaptation mechanisms of L. monocytogenes was confirmed in subsequent experiments, thus, providing insight into a multifaceted modulatory function of RNA/mRNA interference. In this review, we discuss the identification of regulatory RNAs by high-throughput techniques and in their functional role in L. monocytogenes.
Keywords: Listeria monocytogenes; sRNA; asRNA; riboswitch; non-coding RNA; regulatory RNA; RNA-Seq; whole genome tiling arrays; infection; UTR Listeria monocytogenes; sRNA; asRNA; riboswitch; non-coding RNA; regulatory RNA; RNA-Seq; whole genome tiling arrays; infection; UTR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Izar, B.; Mraheil, M.A.; Hain, T. Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes. Int. J. Mol. Sci. 2011, 12, 5070-5079.

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