Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes
AbstractBacterial regulatory non-coding RNAs control numerous mRNA targets that direct a plethora of biological processes, such as the adaption to environmental changes, growth and virulence. Recently developed high-throughput techniques, such as genomic tiling arrays and RNA-Seq have allowed investigating prokaryotic cis- and trans-acting regulatory RNAs, including sRNAs, asRNAs, untranslated regions (UTR) and riboswitches. As a result, we obtained a more comprehensive view on the complexity and plasticity of the prokaryotic genome biology. Listeria monocytogenes was utilized as a model system for intracellular pathogenic bacteria in several studies, which revealed the presence of about 180 regulatory RNAs in the listerial genome. A regulatory role of non-coding RNAs in survival, virulence and adaptation mechanisms of L. monocytogenes was confirmed in subsequent experiments, thus, providing insight into a multifaceted modulatory function of RNA/mRNA interference. In this review, we discuss the identification of regulatory RNAs by high-throughput techniques and in their functional role in L. monocytogenes.
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Izar, B.; Mraheil, M.A.; Hain, T. Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes. Int. J. Mol. Sci. 2011, 12, 5070-5079.
Izar B, Mraheil MA, Hain T. Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes. International Journal of Molecular Sciences. 2011; 12(8):5070-5079.Chicago/Turabian Style
Izar, Benjamin; Mraheil, Mobarak Abu; Hain, Torsten. 2011. "Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes." Int. J. Mol. Sci. 12, no. 8: 5070-5079.