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Int. J. Mol. Sci. 2011, 12(8), 5070-5079; doi:10.3390/ijms12085070
Review

Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes

1,2
, 1
 and 1,*
Received: 28 June 2011; in revised form: 15 July 2011 / Accepted: 8 August 2011 / Published: 10 August 2011
(This article belongs to the Special Issue Non-Coding RNAs)
View Full-Text   |   Download PDF [173 KB, uploaded 19 June 2014]
Abstract: Bacterial regulatory non-coding RNAs control numerous mRNA targets that direct a plethora of biological processes, such as the adaption to environmental changes, growth and virulence. Recently developed high-throughput techniques, such as genomic tiling arrays and RNA-Seq have allowed investigating prokaryotic cis- and trans-acting regulatory RNAs, including sRNAs, asRNAs, untranslated regions (UTR) and riboswitches. As a result, we obtained a more comprehensive view on the complexity and plasticity of the prokaryotic genome biology. Listeria monocytogenes was utilized as a model system for intracellular pathogenic bacteria in several studies, which revealed the presence of about 180 regulatory RNAs in the listerial genome. A regulatory role of non-coding RNAs in survival, virulence and adaptation mechanisms of L. monocytogenes was confirmed in subsequent experiments, thus, providing insight into a multifaceted modulatory function of RNA/mRNA interference. In this review, we discuss the identification of regulatory RNAs by high-throughput techniques and in their functional role in L. monocytogenes.
Keywords: Listeria monocytogenes; sRNA; asRNA; riboswitch; non-coding RNA; regulatory RNA; RNA-Seq; whole genome tiling arrays; infection; UTR Listeria monocytogenes; sRNA; asRNA; riboswitch; non-coding RNA; regulatory RNA; RNA-Seq; whole genome tiling arrays; infection; UTR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Izar, B.; Mraheil, M.A.; Hain, T. Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes. Int. J. Mol. Sci. 2011, 12, 5070-5079.

AMA Style

Izar B, Mraheil MA, Hain T. Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes. International Journal of Molecular Sciences. 2011; 12(8):5070-5079.

Chicago/Turabian Style

Izar, Benjamin; Mraheil, Mobarak Abu; Hain, Torsten. 2011. "Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes." Int. J. Mol. Sci. 12, no. 8: 5070-5079.


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