Int. J. Mol. Sci. 2011, 12(12), 9155-9171; doi:10.3390/ijms12129155
Review

RNA Aptamer Evolution: Two Decades of SELEction

1email and 2,* email
Received: 24 October 2011; in revised form: 24 November 2011 / Accepted: 28 November 2011 / Published: 8 December 2011
(This article belongs to the Special Issue Non-Coding RNAs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed in 1990, the SELEX process has become a powerful tool to select structured oligonucleotides for the recognition of targets, starting with small molecules, going through protein complexes until whole cells. SELEX has also evolved along with new technologies positioning itself as an alternative in the design of a new class of therapeutic agents in modern molecular medicine. This review is an historical follow-up of SELEX method over the two decades since its first appearance.
Keywords: non-coding RNAs; aptamers; SELEX; in vitro selection; in vitro evolution
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MDPI and ACS Style

Aquino-Jarquin, G.; Toscano-Garibay, J.D. RNA Aptamer Evolution: Two Decades of SELEction. Int. J. Mol. Sci. 2011, 12, 9155-9171.

AMA Style

Aquino-Jarquin G, Toscano-Garibay JD. RNA Aptamer Evolution: Two Decades of SELEction. International Journal of Molecular Sciences. 2011; 12(12):9155-9171.

Chicago/Turabian Style

Aquino-Jarquin, Guillermo; Toscano-Garibay, Julia D. 2011. "RNA Aptamer Evolution: Two Decades of SELEction." Int. J. Mol. Sci. 12, no. 12: 9155-9171.


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