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RNA Aptamer Evolution: Two Decades of SELEction
AbstractAptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed in 1990, the SELEX process has become a powerful tool to select structured oligonucleotides for the recognition of targets, starting with small molecules, going through protein complexes until whole cells. SELEX has also evolved along with new technologies positioning itself as an alternative in the design of a new class of therapeutic agents in modern molecular medicine. This review is an historical follow-up of SELEX method over the two decades since its first appearance.
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Aquino-Jarquin, G.; Toscano-Garibay, J.D. RNA Aptamer Evolution: Two Decades of SELEction. Int. J. Mol. Sci. 2011, 12, 9155-9171.View more citation formats
Aquino-Jarquin G, Toscano-Garibay JD. RNA Aptamer Evolution: Two Decades of SELEction. International Journal of Molecular Sciences. 2011; 12(12):9155-9171.Chicago/Turabian Style
Aquino-Jarquin, Guillermo; Toscano-Garibay, Julia D. 2011. "RNA Aptamer Evolution: Two Decades of SELEction." Int. J. Mol. Sci. 12, no. 12: 9155-9171.
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