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MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis
Genomics Sciences Program, Oncogenomics and Cancer Proteomics Laboratory, Autonomous University of Mexico City, Avenue San Lorenzo 290, 03100, Mexico
Biotechnology Program, Institutional Program of Molecular Biomedicine, National School of Medicine and Homeopathy of the National Polytechnic Institute, Guillermo Massieu Helguera 239, 07320, Mexico
Carcinogenesis Laboratory, National Institute of Cancerology, Avenue San Fernando 22, 14080, Mexico
Massive Sequencing Unit, National Institute of Cancerology, Avenue San Fernando 22, 14080, Mexico
Genomics Laboratory, FES-I, UBIMED, National Autonomous University of Mexico, Avenue de los Barrios 1, 54090, Mexico
Academic Unit of Biological Chemistry Sciences, Molecular Biomedicine Laboratory, Autonomous University of Guerrero, Lazaro Cárdenas S/N Col, Haciendita, Chilpancingo Guerrero, 39090, Mexico
Institute of Breast Diseases-FUCAM, Avenue Bordo 100, 04980, Mexico
* Author to whom correspondence should be addressed.
Received: 28 November 2011; in revised form: 9 January 2012 / Accepted: 9 January 2012 / Published: 27 January 2012
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression.
Keywords: microRNA; cancer; epithelial-mesenchymal transition; invasion; metastasis; metastamiRs
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Lopez-Camarillo, C.; Marchat, L.A.; Arechaga-Ocampo, E.; Perez-Plasencia, C.; Moral-Hernandez, O.; Castaneda-Ortiz, E.J.; Rodriguez-Cuevas, S. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis. Int. J. Mol. Sci. 2012, 13, 1347-1379.
Lopez-Camarillo C, Marchat LA, Arechaga-Ocampo E, Perez-Plasencia C, Moral-Hernandez O, Castaneda-Ortiz EJ, Rodriguez-Cuevas S. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis. International Journal of Molecular Sciences. 2012; 13(2):1347-1379.
Lopez-Camarillo, Cesar; Marchat, Laurence A.; Arechaga-Ocampo, Elena; Perez-Plasencia, Carlos; Moral-Hernandez, Oscar del; Castaneda-Ortiz, Elizabeth J.; Rodriguez-Cuevas, Sergio. 2012. "MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis." Int. J. Mol. Sci. 13, no. 2: 1347-1379.