Int. J. Mol. Sci. 2012, 13(2), 1347-1379; doi:10.3390/ijms13021347
Article

MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis

1,* email, 2email, 3email, 4,5email, 6email, 1email and 7email
Received: 28 November 2011; in revised form: 9 January 2012 / Accepted: 9 January 2012 / Published: 27 January 2012
(This article belongs to the Special Issue Non-Coding RNAs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression.
Keywords: microRNA; cancer; epithelial-mesenchymal transition; invasion; metastasis; metastamiRs
PDF Full-text Download PDF Full-Text [1073 KB, Updated Version, uploaded 19 June 2014 04:10 CEST]
The original version is still available [1688 KB, uploaded 19 June 2014 04:10 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Lopez-Camarillo, C.; Marchat, L.A.; Arechaga-Ocampo, E.; Perez-Plasencia, C.; Moral-Hernandez, O.; Castaneda-Ortiz, E.J.; Rodriguez-Cuevas, S. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis. Int. J. Mol. Sci. 2012, 13, 1347-1379.

AMA Style

Lopez-Camarillo C, Marchat LA, Arechaga-Ocampo E, Perez-Plasencia C, Moral-Hernandez O, Castaneda-Ortiz EJ, Rodriguez-Cuevas S. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis. International Journal of Molecular Sciences. 2012; 13(2):1347-1379.

Chicago/Turabian Style

Lopez-Camarillo, Cesar; Marchat, Laurence A.; Arechaga-Ocampo, Elena; Perez-Plasencia, Carlos; Moral-Hernandez, Oscar del; Castaneda-Ortiz, Elizabeth J.; Rodriguez-Cuevas, Sergio. 2012. "MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis." Int. J. Mol. Sci. 13, no. 2: 1347-1379.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert