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Int. J. Mol. Sci. 2012, 13(2), 1347-1379; doi:10.3390/ijms13021347
Article

MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis

1,* , 2
, 3
, 4,5
, 6
, 1
 and 7
1 Genomics Sciences Program, Oncogenomics and Cancer Proteomics Laboratory, Autonomous University of Mexico City, Avenue San Lorenzo 290, 03100, Mexico 2 Biotechnology Program, Institutional Program of Molecular Biomedicine, National School of Medicine and Homeopathy of the National Polytechnic Institute, Guillermo Massieu Helguera 239, 07320, Mexico 3 Carcinogenesis Laboratory, National Institute of Cancerology, Avenue San Fernando 22, 14080, Mexico 4 Massive Sequencing Unit, National Institute of Cancerology, Avenue San Fernando 22, 14080, Mexico 5 Genomics Laboratory, FES-I, UBIMED, National Autonomous University of Mexico, Avenue de los Barrios 1, 54090, Mexico 6 Academic Unit of Biological Chemistry Sciences, Molecular Biomedicine Laboratory, Autonomous University of Guerrero, Lazaro Cárdenas S/N Col, Haciendita, Chilpancingo Guerrero, 39090, Mexico 7 Institute of Breast Diseases-FUCAM, Avenue Bordo 100, 04980, Mexico
* Author to whom correspondence should be addressed.
Received: 28 November 2011 / Revised: 9 January 2012 / Accepted: 9 January 2012 / Published: 27 January 2012
(This article belongs to the Special Issue Non-Coding RNAs)
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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression.
Keywords: microRNA; cancer; epithelial-mesenchymal transition; invasion; metastasis; metastamiRs microRNA; cancer; epithelial-mesenchymal transition; invasion; metastasis; metastamiRs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lopez-Camarillo, C.; Marchat, L.A.; Arechaga-Ocampo, E.; Perez-Plasencia, C.; Moral-Hernandez, O.; Castaneda-Ortiz, E.J.; Rodriguez-Cuevas, S. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis. Int. J. Mol. Sci. 2012, 13, 1347-1379.

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