Special Issue "Bioactivity of Marine Natural Products"
Deadline for manuscript submissions: closed (30 October 2015)
Prof. Vassilios Roussis
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, GR 15771, Athens, Greece
Phone: +30210 7274 592
Fax: +30 210 7274 592
Interests: marine natural products; chemotaxonomy; chemical ecology
Assist. Prof. Efstathia Ioannou
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
Website | E-Mail
Interests: marine natural products; structure elucidation; bioactivity evaluation; marine-derived microorganisms; biotransformations
Nature is the richest source of both biological and chemical diversity. Also, natural products still provide the majority of the world with their pharmacopoeia.
The marine environment, which represents approximately half of the global biodiversity, is estimated to have between 3 and 500 million different species; the environment represents an enormous resource for novel compounds. However, the abundant floras and faunas inhabiting the 70% of the Earth’s surface that is covered by ocean still remains relatively unexplored.
More than 25,000 marine natural products have been discovered, with a marked increase in recent years. Most of the marine organisms have provided a seemingly endless parade of very unusual novel structures, often possessing functional groups appearing uniquely or predominantly in the marine environment. One particularly recurring feature is the presence of halogen atoms, which can be related to the relative abundance of these elements in the marine environment.
In the last decade the compounds Trabectedin from the colonial tunicate Ecteinascidia turbinata and Ziconotide, the synthetic form of an ω-conotoxin peptide, from the cone snail Conus magus were approved for the treatment of advanced soft tissue sarcoma and the amelioration of severe and chronic pains, respectively. Besides them, through the combined efforts of marine natural product chemists and pharmacologists a number of promising compounds are already at advanced stages of clinical trials or have been selected as promising candidates. Marine toxins produced in most cases by microorganisms, such as dinoflagellates or marine bacteria, represent one of the most challenging areas of marine chemistry and pharmacology.
This issue focuses on natural products derived from marine macro- and microorganisms with special emphasis on their biological activities and their potential as pharmaceuticals. Articles and mini reviews on ecological roles, structure-activity relationships, and reports of new bioactive marine metabolites are welcome.
Prof. Dr. Vassilios Roussis
Dr. Efstathia Ioannou
Manuscript Submission Information
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- Bioactive marine natural products
- pharmacological activity
- chemical ecology
- antifouling activity
- marine toxins
- structure-activity relationships