Next Article in Journal
Metabolite Profiling of Diverse Rice Germplasm and Identification of Conserved Metabolic Markers of Rice Roots in Response to Long-Term Mild Salinity Stress
Next Article in Special Issue
The Use of a Liposomal Formulation Incorporating an Antimicrobial Peptide from Tilapia as a New Adjuvant to Epirubicin in Human Squamous Cell Carcinoma and Pluripotent Testicular Embryonic Carcinoma Cells
Previous Article in Journal
Effects of Oral Administration of Chitin Nanofiber on Plasma Metabolites and Gut Microorganisms
Previous Article in Special Issue
4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(9), 21950-21958; doi:10.3390/ijms160921950

New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix

1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
3
Department of Pharmacy of Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan
4
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
5
Division of Surgical Oncology, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
6
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
7
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
8
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
9
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
10
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Vassilios Roussis and Efstathia Ioannou
Received: 7 August 2015 / Revised: 31 August 2015 / Accepted: 7 September 2015 / Published: 11 September 2015
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
View Full-Text   |   Download PDF [764 KB, uploaded 11 September 2015]   |  

Abstract

Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC50 ≤ 5.0 μM). View Full-Text
Keywords: Ircinia felix; sponge; homoscalarane; sesterterpenoid; cytotoxicity Ircinia felix; sponge; homoscalarane; sesterterpenoid; cytotoxicity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lai, Y.-Y.; Chen, L.-C.; Wu, C.-F.; Lu, M.-C.; Wen, Z.-H.; Wu, T.-Y.; Fang, L.-S.; Wang, L.-H.; Wu, Y.-C.; Sung, P.-J. New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix. Int. J. Mol. Sci. 2015, 16, 21950-21958.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top