Special Issue "Bioactive Halogenated Metabolites of Marine Origin"


A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 June 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Vassilios Roussis
University of Athens, School of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products, Panepistimiopolis Zografou, GR 15771, Athens, Greece
E-Mail: roussis@pharm.uoa.gr
Phone: +30 210 7274 592
Fax: +30 210 7274 592
Interests: marine natural products; chemotaxonomy; chemical ecology

Special Issue Information

Dear Colleagues,

Halogenated secondary metabolites, while rare in terrestrial plants, are common in marine organisms due to the abundance of chloride and bromide ions in seawater. Marine biota produce a variety of halogen containing organic compounds that have 1-30 carbon atoms. Organisms that have the ability to form halogenated compounds have been found among various species of algae, bacteria, sponges, mollusks, coelenterates and several marine worms.

Interestingly, bromine is the most commonly found halogen in marine natural products, even though its concentration in seawater is lower than that of chlorine. Of all marine organisms, algae possess the highest abundance of unique biosynthetic pathways for organohalogen production.

Seaweeds probably produce halogenated organics as part of a defense system against microorganism infections, herbivore grazing, space competitors, detrimental fouling by different kinds of epiphytes, or excess of self-generated hypochlorite and hydrogen peroxide. The chemotaxonomic value of these compounds has been seriously considered in the past but the geographic and seasonal variation in the chemical composition of algal species has reduced their importance.

A significant number of algal halogenated metabolites have exhibited an impressive array of biological properties ranging from antimicrobial to insecticidal activities.

Prof. Dr. Vassilios Roussis
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • biosynthesis
  • structure elucidation
  • bioactivity
  • chemotaxonomy
  • chemical ecology
  • pharmacological activity

Published Papers (5 papers)

by , , ,  and
Mar. Drugs 2014, 12(8), 4417-4438; doi:10.3390/md12084417
Received: 3 June 2014; in revised form: 23 July 2014 / Accepted: 24 July 2014 / Published: 8 August 2014
Show/Hide Abstract | PDF Full-text (1984 KB) | HTML Full-text | XML Full-text | Supplementary Files

by ,  and
Mar. Drugs 2010, 8(8), 2301-2317; doi:10.3390/md8082301
Received: 30 June 2010; in revised form: 23 July 2010 / Accepted: 2 August 2010 / Published: 9 August 2010
Show/Hide Abstract | Cited by 30 | PDF Full-text (214 KB) | HTML Full-text | XML Full-text

by , , ,  and
Mar. Drugs 2010, 8(6), 1743-1749; doi:10.3390/md8061743
Received: 4 May 2010; Accepted: 14 May 2010 / Published: 26 May 2010
Show/Hide Abstract | Cited by 9 | PDF Full-text (178 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Mar. Drugs 2010, 8(5), 1526-1549; doi:10.3390/md8051526
Received: 2 March 2010; in revised form: 19 April 2010 / Accepted: 23 April 2010 / Published: 28 April 2010
Show/Hide Abstract | Cited by 19 | PDF Full-text (349 KB) | HTML Full-text | XML Full-text

by , ,  and
Mar. Drugs 2010, 8(4), 988-1010; doi:10.3390/md8040988
Received: 25 February 2010; in revised form: 13 March 2010 / Accepted: 25 March 2010 / Published: 30 March 2010
Show/Hide Abstract | Cited by 22 | PDF Full-text (655 KB) | HTML Full-text | XML Full-text

Last update: 12 November 2013

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