4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo
AbstractIn this study, we screened compounds with skin whitening properties and favorable safety profiles from a series of marine related natural products, which were isolated from Formosan soft coral Cladiella australis. Our results indicated that 4-(phenylsulfanyl)butan-2-one could successfully inhibit pigment generation processes in mushroom tyrosinase platform assay, probably through the suppression of tyrosinase activity to be a non-competitive inhibitor of tyrosinase. In cell-based viability examinations, it demonstrated low cytotoxicity on melanoma cells and other normal human cells. It exhibited stronger inhibitions of melanin production and tyrosinase activity than arbutin or 1-phenyl-2-thiourea (PTU). Also, we discovered that 4-(phenylsulfanyl)butan-2-one reduces the protein expressions of melanin synthesis-related proteins, including the microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (Trp-1), dopachrome tautomerase (DCT, Trp-2), and glycoprotein 100 (GP100). In an in vivo zebrafish model, it presented a remarkable suppression in melanogenesis after 48 h. In summary, our in vitro and in vivo biological assays showed that 4-(phenylsulfanyl)butan-2-one possesses anti-melanogenic properties that are significant in medical cosmetology. View Full-Text
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Wu, S.-Y.S.; Wang, H.-M.D.; Wen, Y.-S.; Liu, W.; Li, P.-H.; Chiu, C.-C.; Chen, P.-C.; Huang, C.-Y.; Sheu, J.-H.; Wen, Z.-H. 4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo. Int. J. Mol. Sci. 2015, 16, 20240-20257.
Wu S-YS, Wang H-MD, Wen Y-S, Liu W, Li P-H, Chiu C-C, Chen P-C, Huang C-Y, Sheu J-H, Wen Z-H. 4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo. International Journal of Molecular Sciences. 2015; 16(9):20240-20257.Chicago/Turabian Style
Wu, Shing-Yi S.; Wang, Hui-Min D.; Wen, Yi-Shan; Liu, Wangta; Li, Pin-Hui; Chiu, Chien-Chih; Chen, Pei-Chin; Huang, Chiung-Yao; Sheu, Jyh-Horng; Wen, Zhi-Hong. 2015. "4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo." Int. J. Mol. Sci. 16, no. 9: 20240-20257.