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Int. J. Mol. Sci. 2015, 16(8), 19508-19517; doi:10.3390/ijms160819508

Terpenoids from the Octocoral Sinularia gaweli

1,2,†
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3,†
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4,5
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6
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7
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8
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3,9,10,11,* and 1,2,3,6,11,*
1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
3
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
4
Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
5
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
6
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
8
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
9
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
10
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
11
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Vassilios Roussis and Efstathia Ioannou
Received: 8 July 2015 / Revised: 6 August 2015 / Accepted: 10 August 2015 / Published: 18 August 2015
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
View Full-Text   |   Download PDF [1135 KB, uploaded 18 August 2015]   |  

Abstract

Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (–)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 24 are new isolates. The structures of new terpenoids 24 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells. View Full-Text
Keywords: Sinularia gaweli; eudesmane; cembrane; octocoral; iNOS Sinularia gaweli; eudesmane; cembrane; octocoral; iNOS
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MDPI and ACS Style

Lin, W.-J.; Wu, T.-Y.; Su, T.-R.; Wen, Z.-H.; Chen, J.-J.; Fang, L.-S.; Wu, Y.-C.; Sung, P.-J. Terpenoids from the Octocoral Sinularia gaweli. Int. J. Mol. Sci. 2015, 16, 19508-19517.

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