Next Article in Journal
The Importance of Thrombin in Cerebral Injury and Disease
Previous Article in Journal
Circulating MicroRNAs as Biomarkers for Sepsis
Previous Article in Special Issue
The Use of a Liposomal Formulation Incorporating an Antimicrobial Peptide from Tilapia as a New Adjuvant to Epirubicin in Human Squamous Cell Carcinoma and Pluripotent Testicular Embryonic Carcinoma Cells
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(1), 79; doi:10.3390/ijms17010079

New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae)

1,2,†
,
3,4,†
,
1,5
,
2,6
,
2,5
,
7
,
8
,
9,10,11,12,* , 1,5,* and 1,2,10,12,13,*
1
Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
3
Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan
4
School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
5
Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University & Academia Sinica, Kaohsiung 804, Taiwan
6
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
7
Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
8
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
9
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
10
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
11
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
12
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
13
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 30 November 2015 / Revised: 30 December 2015 / Accepted: 5 January 2016 / Published: 9 January 2016
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
View Full-Text   |   Download PDF [1194 KB, uploaded 9 January 2016]   |  

Abstract

Six new 9-hydroxybriarane diterpenoids, briarenolides ZI–ZVI (16), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 16 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. View Full-Text
Keywords: Briareum; briarenolide; briarane; gorgonian; anti-inflammatory; iNOS Briareum; briarenolide; briarane; gorgonian; anti-inflammatory; iNOS
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Su, Y.-D.; Sung, C.-S.; Wen, Z.-H.; Chen, Y.-H.; Chang, Y.-C.; Chen, J.-J.; Fang, L.-S.; Wu, Y.-C.; Sheu, J.-H.; Sung, P.-J. New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae). Int. J. Mol. Sci. 2016, 17, 79.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top