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Int. J. Mol. Sci. 2015, 16(4), 6902-6910; doi:10.3390/ijms16046902

Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models

1
Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 380-150, Korea
2
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science & Technology, 787 Haeanro, Ansan 426-744, Korea
3
Division of Biological Science and Technology, Yonsei University, Wonju 222-710, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 10 February 2015 / Revised: 7 March 2015 / Accepted: 16 March 2015 / Published: 26 March 2015
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
View Full-Text   |   Download PDF [1565 KB, uploaded 26 March 2015]   |  

Abstract

Streptochlorin, a small compound derived from marine actinomycete, has been shown to have anti-angiogenic, anti-tumor, and anti-allergic activities. However, the anti-inflammatory effects and underlying mechanisms have not yet been reported. In the present study, we investigated the effect of streptochlorin on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. Streptochlorin attenuated the production of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1β, and IL-6 in LPS-stimulated RAW264.7 cells through inhibition of the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon-β (TRIF)-dependent signaling pathway. Furthermore, streptochlorin suppressed the infiltration of immune cells such as neutrophils into the lung and proinflammatory cytokine production such as IL-6 and TNF-α in broncho-alveolar lavage fluid (BALF) in the LPS-induced acute lung injury (ALI) mouse model. Streptochlorin has potent anti-inflammatory effects through regulating TRIF-dependent signaling pathways, suggesting that streptochlorin may provide a valuable therapeutic strategy in treating various inflammatory diseases. View Full-Text
Keywords: streptochlorin; LPS; anti-inflammation; TRIF; ALI streptochlorin; LPS; anti-inflammation; TRIF; ALI
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shim, D.-W.; Shin, H.J.; Han, J.-W.; Shin, W.-Y.; Sun, X.; Shim, E.-J.; Kim, T.-J.; Kang, T.-B.; Lee, K.-H. Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models. Int. J. Mol. Sci. 2015, 16, 6902-6910.

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