Special Issue "ADMA and Nitrergic System"
Deadline for manuscript submissions: 30 December 2013
Dr. Graziano Riccioni
Studio Medico Polispecialistico, Via Magenta 106, San Severo, 71016 Foggia, Italy
Phone: +39 3664694444
Fax: +39 882227022
Interests: atherosclerosis; statins; ivabradine; ischemic cardiac disease; antioxidants; endothelial dyfunction and metabolities; carotenoids
Dr. Lorenza Speranza
Department of Medicine and Science of Aging, Applied Biology, “G. D’Annunzio” University, Chieti-Pescara, Italy
Phone: +39 0 8713554550
Fax: +39 0 8713554551
Interests: Oxidative stress; nitric oxide; nitric oxide synthase; natural compounds; asymmetric dimethylarginine; aging; brain natriuretic peptide; interleukin
Nitric oxide (NO) is one of the most important mediators synthesized from L-arginine by a family of NO synthases (NOS), involved in the regulation of vascular tone, neurotransmission in the central and peripheral nervous system, and regulation of mitochondrial respiration. The availability of NO in a given cell depends on many factors including expression and activity of several NOS (neuronal, inducible, and endothelial), abundance of NOS substrate, L-arginine, and its cofactor, tetrahydrobiopterin. NO production may also be regulated by endogenous NOS inhibitors, in particular asymmetric dimethylarginine (ADMA), synthesized during the methylation of protein arginine residues by protein arginine. ADMA is a competitive inhibitor of NOS, decrease NO availability and is eliminated by renal excretion or metabolized by dimethylarginine dimethylaminohydrolases (DDAH) to citruline and dimethylamine. Two other endogenous methylarginines are also synthesized by protein-arginine methyltransferases (PRMT): N-monomethyl-L-arginine (L-NMMA) and symmetric dimethylarginine (SDMA).
Plasma concentration of ADMA is increased in patients with hyperlipidemia, diabetes mellitus, arterial hypertension, hyperhomocysteinemia, heart and chronic renal failure. The increased concentration of ADMA is positively correlated with markers of atherosclerosis, such as carotid artery intima-media thickness and has a predictive value for acute cardiovascular events.
There is no doubt that ADMA regulate NOS activity under physiological and pathological conditions, is increased in many diseases in which NO deficiency, is metabolized by the endothelium and may represent an important index of endothelial dysfunction. The possibility to modulate ADMA by pharmacotherapy is a new and important approach of many acute and chronic disease and is still of great interest. Some medication such angiotensin converting enzyme inhibitors and angiotensin AT1 receptor antagonists, fibrates, metformin, antioxidant vitamins, aspirin, n-3 polyunsaturated fatty acids and flavonoids are drugs and substances which have shown to reduce ADMA levels in humans with the improvement of NO synthesis. Agents modifying ADMA concentrations should be considered in the treatment of many chronic diseases.
Dr. Graziano Riccioni
Dr. Lorenza Speranza
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- asymmetric dimethylarginine
- nitric oxide; nitric oxide synthase
- symmetric dimethylarginine
- dimethylarginine dimethylaminohydrolases
- protein-arginine methyltransferases
- reactive oxygen species
Int. J. Mol. Sci. 2012, 13(6), 7521-7531; doi:10.3390/ijms13067521
Received: 2 May 2012; in revised form: 7 June 2012 / Accepted: 13 June 2012 / Published: 18 June 2012| Download PDF Full-text (256 KB) | Download XML Full-text
Int. J. Mol. Sci. 2012, 13(9), 11288-11311; doi:10.3390/ijms130911288
Received: 2 August 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 10 September 2012| Download PDF Full-text (633 KB) | Download XML Full-text
Review: Asymmetric Dimethylarginine as a Surrogate Marker of Endothelial Dysfunction and Cardiovascular Risk in Patients with Systemic Rheumatic Diseases
Int. J. Mol. Sci. 2012, 13(10), 12315-12335; doi:10.3390/ijms131012315
Received: 20 August 2012; in revised form: 15 September 2012 / Accepted: 19 September 2012 / Published: 26 September 2012| Download PDF Full-text (364 KB) | Download XML Full-text
Review: Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
Int. J. Mol. Sci. 2012, 13(10), 12383-12400; doi:10.3390/ijms131012383
Received: 3 September 2012; in revised form: 19 September 2012 / Accepted: 19 September 2012 / Published: 27 September 2012| Download PDF Full-text (275 KB) | Download XML Full-text
Int. J. Mol. Sci. 2012, 13(11), 14606-14622; doi:10.3390/ijms131114606
Received: 12 July 2012; in revised form: 17 October 2012 / Accepted: 7 November 2012 / Published: 9 November 2012| Download PDF Full-text (307 KB) | Download XML Full-text
Article: Associations between Endogenous Dimethylarginines and Renal Function in Healthy Children and Adolescents
Int. J. Mol. Sci. 2012, 13(11), 15464-15474; doi:10.3390/ijms131115464
Received: 9 November 2012; in revised form: 16 November 2012 / Accepted: 19 November 2012 / Published: 21 November 2012| Download PDF Full-text (219 KB) | Download XML Full-text
Int. J. Mol. Sci. 2012, 13(12), 15983-16004; doi:10.3390/ijms131215983
Received: 28 September 2012; in revised form: 14 November 2012 / Accepted: 21 November 2012 / Published: 28 November 2012| Download PDF Full-text (334 KB) | Download XML Full-text
Technical Note: Determination of Homoarginine, Arginine, NMMA, ADMA, and SDMA in Biological Samples by HPLC-ESI-Mass Spectrometry
Int. J. Mol. Sci. 2013, 14(10), 20131-20138; doi:10.3390/ijms141020131
Received: 29 July 2013; in revised form: 28 August 2013 / Accepted: 18 September 2013 / Published: 9 October 2013| Download PDF Full-text (208 KB) | Download XML Full-text
Article: Opposite Associations of Plasma Homoarginine and Ornithine with Arginine in Healthy Children and Adolescents
Int. J. Mol. Sci. 2013, 14(11), 21819-21832; doi:10.3390/ijms141121819
Received: 12 August 2013; in revised form: 20 September 2013 / Accepted: 9 October 2013 / Published: 4 November 2013| Download PDF Full-text (227 KB) | Download XML Full-text
Last update: 12 April 2013