Special Issue "ADMA and Nitrergic System"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (30 December 2013)

Special Issue Editors

Guest Editor
Dr. Graziano Riccioni
Studio Medico Polispecialistico, Via Magenta 106, San Severo, 71016 Foggia, Italy
Website: http://www.docvadis.it/graziano.riccioni/index.html
E-Mail: griccioni@hotmail.com
Phone: +39 3664694444
Fax: +39 882227022
Interests: atherosclerosis; statins; ivabradine; ischemic cardiac disease; antioxidants; endothelial dyfunction and metabolities; carotenoids

Guest Editor
Dr. Lorenza Speranza
Department of Medicine and Science of Aging, Applied Biology, “G. D’Annunzio” University, Chieti-Pescara, Italy
E-Mail: l.speranza@unich.it
Phone: +39 0 8713554550
Fax: +39 0 8713554551
Interests: Oxidative stress; nitric oxide; nitric oxide synthase; natural compounds; asymmetric dimethylarginine; aging; brain natriuretic peptide; interleukin

Special Issue Information

Dear Colleagues,

Nitric oxide (NO) is one of the most important mediators synthesized from L-arginine by a family of NO synthases (NOS),  involved in the regulation of vascular tone, neurotransmission in the central and peripheral nervous system, and regulation of mitochondrial respiration. The availability of NO in a given cell depends on many factors including expression and activity of several NOS (neuronal, inducible, and endothelial), abundance of NOS substrate, L-arginine, and its cofactor, tetrahydrobiopterin. NO production may also be regulated by endogenous NOS inhibitors, in particular asymmetric dimethylarginine (ADMA), synthesized during the methylation of protein arginine residues by protein arginine. ADMA is a competitive inhibitor of NOS, decrease NO availability and is eliminated by renal excretion or metabolized by dimethylarginine dimethylaminohydrolases (DDAH) to citruline and dimethylamine. Two other endogenous methylarginines are also synthesized by protein-arginine methyltransferases (PRMT): N-monomethyl-L-arginine (L-NMMA) and symmetric dimethylarginine (SDMA).

Plasma concentration of ADMA is increased in patients with hyperlipidemia, diabetes mellitus, arterial hypertension, hyperhomocysteinemia, heart and chronic renal failure. The increased concentration of ADMA is positively correlated with markers of atherosclerosis, such as carotid artery intima-media thickness and has a predictive value for acute cardiovascular events.

There is no doubt that ADMA regulate NOS activity under physiological and pathological conditions, is increased in many diseases in which NO deficiency, is metabolized by the endothelium and may represent an important index of endothelial dysfunction. The possibility to modulate ADMA by pharmacotherapy is a new and important approach of many acute and chronic disease and is still of great interest. Some medication such angiotensin converting enzyme inhibitors and angiotensin AT1 receptor antagonists, fibrates, metformin, antioxidant vitamins, aspirin, n-3 polyunsaturated fatty acids and flavonoids are drugs and substances which have shown to reduce ADMA levels in humans with the improvement of NO synthesis. Agents modifying ADMA concentrations should be considered in the treatment of many chronic diseases.

Dr. Graziano Riccioni
Dr. Lorenza Speranza
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

  • asymmetric dimethylarginine
  • nitric oxide; nitric oxide synthase
  • symmetric dimethylarginine
  • dimethylarginine dimethylaminohydrolases
  • N-monomethyl-L-arginine
  • protein-arginine methyltransferases
  • reactive oxygen species

Published Papers (17 papers)

by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 6391-6398; doi:10.3390/ijms15046391
Received: 1 January 2014; in revised form: 2 March 2014 / Accepted: 10 March 2014 / Published: 15 April 2014
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by , , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 6062-6071; doi:10.3390/ijms15046062
Received: 30 December 2013; in revised form: 7 March 2014 / Accepted: 31 March 2014 / Published: 10 April 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 5522-5535; doi:10.3390/ijms15045522
Received: 17 February 2014; in revised form: 18 March 2014 / Accepted: 24 March 2014 / Published: 31 March 2014
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by , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4946-4964; doi:10.3390/ijms15034946
Received: 27 December 2013; in revised form: 3 March 2014 / Accepted: 4 March 2014 / Published: 20 March 2014
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by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4088-4103; doi:10.3390/ijms15034088
Received: 30 December 2013; in revised form: 14 February 2014 / Accepted: 3 March 2014 / Published: 6 March 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(3), 3989-4006; doi:10.3390/ijms15033989
Received: 5 December 2013; in revised form: 4 February 2014 / Accepted: 26 February 2014 / Published: 5 March 2014
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by , , , ,  and
Int. J. Mol. Sci. 2014, 15(1), 1189-1200; doi:10.3390/ijms15011189
Received: 10 December 2013; in revised form: 7 January 2014 / Accepted: 8 January 2014 / Published: 17 January 2014
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by , , ,  and
Int. J. Mol. Sci. 2013, 14(12), 24412-24421; doi:10.3390/ijms141224412
Received: 29 October 2013; in revised form: 5 December 2013 / Accepted: 6 December 2013 / Published: 16 December 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (257 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(11), 21819-21832; doi:10.3390/ijms141121819
Received: 12 August 2013; in revised form: 20 September 2013 / Accepted: 9 October 2013 / Published: 4 November 2013
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by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(10), 20131-20138; doi:10.3390/ijms141020131
Received: 29 July 2013; in revised form: 28 August 2013 / Accepted: 18 September 2013 / Published: 9 October 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (208 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(12), 15983-16004; doi:10.3390/ijms131215983
Received: 28 September 2012; in revised form: 14 November 2012 / Accepted: 21 November 2012 / Published: 28 November 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (334 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(11), 15464-15474; doi:10.3390/ijms131115464
Received: 9 November 2012; in revised form: 16 November 2012 / Accepted: 19 November 2012 / Published: 21 November 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (219 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2012, 13(11), 14606-14622; doi:10.3390/ijms131114606
Received: 12 July 2012; in revised form: 17 October 2012 / Accepted: 7 November 2012 / Published: 9 November 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (307 KB) | HTML Full-text | XML Full-text

by , , ,  and
Int. J. Mol. Sci. 2012, 13(10), 12383-12400; doi:10.3390/ijms131012383
Received: 3 September 2012; in revised form: 19 September 2012 / Accepted: 19 September 2012 / Published: 27 September 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (275 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2012, 13(10), 12315-12335; doi:10.3390/ijms131012315
Received: 20 August 2012; in revised form: 15 September 2012 / Accepted: 19 September 2012 / Published: 26 September 2012
Show/Hide Abstract | Cited by 7 | PDF Full-text (364 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2012, 13(9), 11288-11311; doi:10.3390/ijms130911288
Received: 2 August 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 10 September 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (633 KB) | HTML Full-text | XML Full-text
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by  and
Int. J. Mol. Sci. 2012, 13(6), 7521-7531; doi:10.3390/ijms13067521
Received: 2 May 2012; in revised form: 7 June 2012 / Accepted: 13 June 2012 / Published: 18 June 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (256 KB) | HTML Full-text | XML Full-text

Last update: 12 April 2013

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