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Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig-University Giessen, Rudolf-Buchheim-Str. 7, D-35385 Giessen, Germany
Department of Biochemistry, Faculty of Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research, Giessen, Germany
Department of Internal Medicine, Faculty of Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research, Giessen, Germany
* Author to whom correspondence should be addressed.
Received: 3 September 2012; in revised form: 19 September 2012 / Accepted: 19 September 2012 / Published: 27 September 2012
Abstract: Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease.
Keywords: protein arginine methylation; PRMT; chronic lung disease
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MDPI and ACS Style
Zakrzewicz, D.; Zakrzewicz, A.; Preissner, K.T.; Markart, P.; Wygrecka, M. Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders. Int. J. Mol. Sci. 2012, 13, 12383-12400.
Zakrzewicz D, Zakrzewicz A, Preissner KT, Markart P, Wygrecka M. Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders. International Journal of Molecular Sciences. 2012; 13(10):12383-12400.
Zakrzewicz, Dariusz; Zakrzewicz, Anna; Preissner, Klaus T.; Markart, Philipp; Wygrecka, Malgorzata. 2012. "Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders." Int. J. Mol. Sci. 13, no. 10: 12383-12400.