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Int. J. Mol. Sci. 2012, 13(10), 12383-12400; doi:10.3390/ijms131012383
Review

Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders

1,* , 2
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 and 3
Received: 3 September 2012; in revised form: 19 September 2012 / Accepted: 19 September 2012 / Published: 27 September 2012
(This article belongs to the Special Issue ADMA and Nitrergic System)
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Abstract: Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease.
Keywords: protein arginine methylation; PRMT; chronic lung disease protein arginine methylation; PRMT; chronic lung disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zakrzewicz, D.; Zakrzewicz, A.; Preissner, K.T.; Markart, P.; Wygrecka, M. Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders. Int. J. Mol. Sci. 2012, 13, 12383-12400.

AMA Style

Zakrzewicz D, Zakrzewicz A, Preissner KT, Markart P, Wygrecka M. Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders. International Journal of Molecular Sciences. 2012; 13(10):12383-12400.

Chicago/Turabian Style

Zakrzewicz, Dariusz; Zakrzewicz, Anna; Preissner, Klaus T.; Markart, Philipp; Wygrecka, Malgorzata. 2012. "Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders." Int. J. Mol. Sci. 13, no. 10: 12383-12400.


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