Int. J. Mol. Sci. 2012, 13(11), 14606-14622; doi:10.3390/ijms131114606
Review

Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming

1,2,†email, 3,4,†email, 5email and 1,6,* email
Received: 12 July 2012; in revised form: 17 October 2012 / Accepted: 7 November 2012 / Published: 9 November 2012
(This article belongs to the Special Issue ADMA and Nitrergic System)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Nitric oxide (NO) regulates placental blood flow and actively participates in trophoblast invasion and placental development. Asymmetric dimethylarginine (ADMA) can inhibit NO synthase, which generates NO. ADMA has been associated with uterine artery flow disturbances such as preeclampsia. Substantial experimental evidence has reliably supported the hypothesis that an adverse in utero environment plays a role in postnatal physiological and pathophysiological programming. Growing evidence suggests that the placental nitrergic system is involved in epigenetic fetal programming. In this review, we discuss the roles of NO and ADMA in normal and compromised pregnancies as well as the link between placental insufficiency and epigenetic fetal programming.
Keywords: asymmetric dimethylarginine; Nitric oxide; nitrergic; fetal programming; placenta
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MDPI and ACS Style

Huang, L.-T.; Hsieh, C.-S.; Chang, K.-A.; Tain, Y.-L. Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming. Int. J. Mol. Sci. 2012, 13, 14606-14622.

AMA Style

Huang L-T, Hsieh C-S, Chang K-A, Tain Y-L. Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming. International Journal of Molecular Sciences. 2012; 13(11):14606-14622.

Chicago/Turabian Style

Huang, Li-Tung; Hsieh, Chih-Sung; Chang, Kow-Aung; Tain, You-Lin. 2012. "Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming." Int. J. Mol. Sci. 13, no. 11: 14606-14622.

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