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Associations between Endogenous Dimethylarginines and Renal Function in Healthy Children and Adolescents
Almed-Elektra Medical Center, 41-710 Ruda Śląska, Poland
Institute for Clinical Pharmacology, Otto-von-Guericke University, 39120 Magdeburg, Germany
Department of Cardiology, Jagiellonian University/University Hospital, 31-501 Cracow, Poland
Department of Coronary Artery Disease, the John Paul II Hospital, 31-202 Cracow, Poland
Department of Cardiology, Congenital Heart Defects and Electrotherapy, Silesian Center for Heart Diseases in Zabrze, 41-800 Zabrze, Medical University of Silesia, Poland
Department of Pediatrics in Zabrze, 41-800 Zabrze, Medical University of Silesia, Poland
* Author to whom correspondence should be addressed.
Received: 9 November 2012; in revised form: 16 November 2012 / Accepted: 19 November 2012 / Published: 21 November 2012
Abstract: The structural isomer of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), is eliminated almost entirely by urinary excretion and considered a sensitive index of glomerular filtration rate (GFR). However, reports on this relationship in healthy subjects younger than 18 years of age are rare. Therefore, our aim was to investigate relations between endogenous dimethylarginines and renal function indices in healthy children and adolescents. We studied 40 subjects aged 3–18 years free of coexistent diseases or subclinical carotid atherosclerosis. A serum creatinine-derived estimated GFR (eGFR) was calculated by the revised bedside Schwartz equation. L-arginine, ADMA and SDMA were measured by liquid chromatography-tandem mass spectrometry. Mean eGFR was 122 ± 22 (SD) mL/min per 1.73 m2. Creatinine and eGFR exhibited closer correlations with the SDMA/ADMA ratio (r = 0.64, p < 0.0001; r = −0.63, p < 0.0001, respectively) than with SDMA (r = 0.31, p = 0.05; r = −0.35, p = 0.03). Neither creatinine nor eGFR correlated with ADMA or L-arginine. Adjustment for age or height only slightly attenuated the associations between the SDMA/ADMA ratio and eGFR or creatinine. Our findings suggest the superiority of the SDMA/ADMA ratio over SDMA as a renal function index in healthy children. Thus, further studies are warranted to verify our preliminary results in a larger group of subjects below 18 years of age.
Keywords: children; asymmetric dimethylarginine; symmetric dimethylarginine; renal function
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Jaźwińska-Kozuba, A.; Martens-Lobenhoffer, J.; Surdacki, A.; Kruszelnicka, O.; Rycaj, J.; Godula-Stuglik, U.; Bode-Böger, S.M. Associations between Endogenous Dimethylarginines and Renal Function in Healthy Children and Adolescents. Int. J. Mol. Sci. 2012, 13, 15464-15474.
Jaźwińska-Kozuba A, Martens-Lobenhoffer J, Surdacki A, Kruszelnicka O, Rycaj J, Godula-Stuglik U, Bode-Böger SM. Associations between Endogenous Dimethylarginines and Renal Function in Healthy Children and Adolescents. International Journal of Molecular Sciences. 2012; 13(11):15464-15474.
Jaźwińska-Kozuba, Aleksandra; Martens-Lobenhoffer, Jens; Surdacki, Andrzej; Kruszelnicka, Olga; Rycaj, Jarosław; Godula-Stuglik, Urszula; Bode-Böger, Stefanie M. 2012. "Associations between Endogenous Dimethylarginines and Renal Function in Healthy Children and Adolescents." Int. J. Mol. Sci. 13, no. 11: 15464-15474.