Special Issue "Matrix Metalloproteinases in Cancer Progress"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 December 2013)
Prof. Dr. Constance E. Brinckerhoff
Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Rubin 602, 1 Medical Center Drive, Lebanon, NH 03756, USA
Interests: melanoma, breast cancer, lung cancer, signal transduction, protease activated receptor-1 (par-1); angiogenesis, mmp-1, transcription, gene expression
The importance of MMPs in connective tissue remodeling and matrix degradation have been known for a long time. Increasingly, it is recognized that these enzymes have critical roles in signal transduction and gene regulation, and that they may have beneficial functions in normal homeostasis as well as in diseases. This special issue is dedicated to highlighting the more novel and innovative roles of secreted MMPs and their membrane bound counterparts, MT-MMPs, as mediators of cancer progression and as tumor suppressors. In addition, these enzymes may participate in cancers by functioning in organelles, such as exosomes and invadopodia. Thus, with their ubiquitous presence, they continue to represent attractive therapeutic targets and new strategies with improved efficacy are emerging. Finally, innovative models of cancers, such as zebrafish, may provide critical insights into how MMPs contribute to cancer progression.
Prof. Dr. Constance E. Brinckerhoff
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.
- novel roles of MMPs in tumor progression and suppression
- gene regulation
- signal transduction
- model systems
- therapeutic strategies
Review: Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs)
Cancers 2014, 6(3), 1220-1255; doi:10.3390/cancers6031220
Received: 7 March 2014; in revised form: 24 April 2014 / Accepted: 15 May 2014 / Published: 27 June 2014| PDF Full-text (1505 KB) | HTML Full-text | XML Full-text
Review: Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression
Cancers 2014, 6(3), 1298-1327; doi:10.3390/cancers6031298
Received: 4 April 2014; in revised form: 31 May 2014 / Accepted: 9 June 2014 / Published: 27 June 2014| PDF Full-text (721 KB) | HTML Full-text | XML Full-text
Review: Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9/NGAL in Leukaemias
Cancers 2014, 6(2), 796-812; doi:10.3390/cancers6020796
Received: 12 December 2013; in revised form: 21 March 2014 / Accepted: 25 March 2014 / Published: 4 April 2014| PDF Full-text (691 KB) | HTML Full-text | XML Full-text
Cancers 2014, 6(2), 625-645; doi:10.3390/cancers6020625
Received: 8 January 2014; in revised form: 21 February 2014 / Accepted: 4 March 2014 / Published: 25 March 2014| PDF Full-text (578 KB) | HTML Full-text | XML Full-text
Cancers 2014, 6(1), 416-435; doi:10.3390/cancers6010416
Received: 25 December 2013; in revised form: 7 February 2014 / Accepted: 8 February 2014 / Published: 17 February 2014| PDF Full-text (1017 KB) | HTML Full-text | XML Full-text
Review: Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression
Cancers 2014, 6(1), 396-415; doi:10.3390/cancers6010396
Received: 11 December 2013; in revised form: 14 January 2014 / Accepted: 29 January 2014 / Published: 13 February 2014| PDF Full-text (641 KB) | HTML Full-text | XML Full-text
Cancers 2014, 6(1), 366-375; doi:10.3390/cancers6010366
Received: 12 December 2013; in revised form: 24 January 2014 / Accepted: 26 January 2014 / Published: 10 February 2014| Cited by 2 | PDF Full-text (352 KB) | HTML Full-text | XML Full-text
Cancers 2014, 6(1), 240-296; doi:10.3390/cancers6010240
Received: 16 December 2013; in revised form: 20 January 2014 / Accepted: 21 January 2014 / Published: 27 January 2014| Cited by 1 | PDF Full-text (1198 KB) | HTML Full-text | XML Full-text
Last update: 15 July 2013