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Cancers 2014, 6(1), 396-415; doi:10.3390/cancers6010396
Review

Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression

1
, 2
 and 2,*
Received: 11 December 2013; in revised form: 14 January 2014 / Accepted: 29 January 2014 / Published: 13 February 2014
(This article belongs to the Special Issue Matrix Metalloproteinases in Cancer Progress)
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Abstract: Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.
Keywords: matrix metalloproteinase; invasion; angiogenesis; head and neck squamous cell carcinoma matrix metalloproteinase; invasion; angiogenesis; head and neck squamous cell carcinoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Iizuka, S.; Ishimaru, N.; Kudo, Y. Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression. Cancers 2014, 6, 396-415.

AMA Style

Iizuka S, Ishimaru N, Kudo Y. Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression. Cancers. 2014; 6(1):396-415.

Chicago/Turabian Style

Iizuka, Shinji; Ishimaru, Naozumi; Kudo, Yasusei. 2014. "Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression." Cancers 6, no. 1: 396-415.


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