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The Role of Matrix Metalloproteinases in Colorectal Cancer
Division of Gastroenterology and Hepatology, Veterans Affairs Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD 21201, USA
* Author to whom correspondence should be addressed.
Received: 12 December 2013; in revised form: 24 January 2014 / Accepted: 26 January 2014 / Published: 10 February 2014
Abstract: In the United States, colorectal cancer (CRC) is the third leading cause of cancer mortality, with limited treatment options for those with advanced disease. Matrix metalloproteinases (MMPs) are important for maintaining extracellular homeostasis but also play a prominent role in cancer cell invasion and dissemination. Expression levels of MMP-1, -2, -7, -9 and -13 correlate with worse outcomes; MMP-12 expression appears to be protective. Hence, MMPs are attractive therapeutic targets. Previous clinical trials using broad-spectrum MMP inhibitors were disappointing because of off-target toxicity and lack of efficacy. Now, the availability of safer, more selective inhibitors has renewed interest in therapeutic targeting of MMPs.
Keywords: matrix metalloproteinases (MMPs); colorectal cancer; tissue inhibitors of metalloproteinases (TIMPs); matrix metalloproteinase inhibitors (MMPIs)
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Cite This Article
MDPI and ACS Style
Said, A.H.; Raufman, J.-P.; Xie, G. The Role of Matrix Metalloproteinases in Colorectal Cancer. Cancers 2014, 6, 366-375.
Said AH, Raufman J-P, Xie G. The Role of Matrix Metalloproteinases in Colorectal Cancer. Cancers. 2014; 6(1):366-375.
Said, Anan H.; Raufman, Jean-Pierre; Xie, Guofeng. 2014. "The Role of Matrix Metalloproteinases in Colorectal Cancer." Cancers 6, no. 1: 366-375.