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Cancers 2014, 6(1), 366-375; doi:10.3390/cancers6010366
Review

The Role of Matrix Metalloproteinases in Colorectal Cancer

,
 and *
Division of Gastroenterology and Hepatology, Veterans Affairs Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD 21201, USA
* Author to whom correspondence should be addressed.
Received: 12 December 2013 / Revised: 24 January 2014 / Accepted: 26 January 2014 / Published: 10 February 2014
(This article belongs to the Special Issue Matrix Metalloproteinases in Cancer Progress)
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Abstract

In the United States, colorectal cancer (CRC) is the third leading cause of cancer mortality, with limited treatment options for those with advanced disease. Matrix metalloproteinases (MMPs) are important for maintaining extracellular homeostasis but also play a prominent role in cancer cell invasion and dissemination. Expression levels of MMP-1, -2, -7, -9 and -13 correlate with worse outcomes; MMP-12 expression appears to be protective. Hence, MMPs are attractive therapeutic targets. Previous clinical trials using broad-spectrum MMP inhibitors were disappointing because of off-target toxicity and lack of efficacy. Now, the availability of safer, more selective inhibitors has renewed interest in therapeutic targeting of MMPs.
Keywords: matrix metalloproteinases (MMPs); colorectal cancer; tissue inhibitors of metalloproteinases (TIMPs); matrix metalloproteinase inhibitors (MMPIs) matrix metalloproteinases (MMPs); colorectal cancer; tissue inhibitors of metalloproteinases (TIMPs); matrix metalloproteinase inhibitors (MMPIs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Said, A.H.; Raufman, J.-P.; Xie, G. The Role of Matrix Metalloproteinases in Colorectal Cancer. Cancers 2014, 6, 366-375.

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