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MicroRNAs in the Regulation of MMPs and Metastasis
AbstractMicroRNAs are integral molecules in the regulation of numerous physiological cellular processes including cellular differentiation, proliferation, metabolism and apoptosis. Their function transcends normal physiology and extends into several pathological entities including cancer. The matrix metalloproteinases play pivotal roles, not only in tissue remodeling, but also in several physiological and pathological processes, including those supporting cancer progression. Additionally, the contribution of active MMPs in metastatic spread and the establishment of secondary metastasis, via the targeting of several substrates, are also well established. This review focuses on the important miRNAs that have been found to impact cancer progression and metastasis through direct and indirect interactions with the matrix metalloproteinases.
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Abba, M.; Patil, N.; Allgayer, H. MicroRNAs in the Regulation of MMPs and Metastasis. Cancers 2014, 6, 625-645.View more citation formats
Abba M, Patil N, Allgayer H. MicroRNAs in the Regulation of MMPs and Metastasis. Cancers. 2014; 6(2):625-645.Chicago/Turabian Style
Abba, Mohammed; Patil, Nitin; Allgayer, Heike. 2014. "MicroRNAs in the Regulation of MMPs and Metastasis." Cancers 6, no. 2: 625-645.