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Cancers 2014, 6(2), 625-645; doi:10.3390/cancers6020625
Review

MicroRNAs in the Regulation of MMPs and Metastasis

1,2
, 1,2
 and 1,2,*
1 Molecular Oncology of Solid Tumors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany 2 Department of Experimental Surgery, Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1-3, 68135 Mannheim, Germany
* Author to whom correspondence should be addressed.
Received: 8 January 2014 / Revised: 21 February 2014 / Accepted: 4 March 2014 / Published: 25 March 2014
(This article belongs to the Special Issue Matrix Metalloproteinases in Cancer Progress)
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Abstract

MicroRNAs are integral molecules in the regulation of numerous physiological cellular processes including cellular differentiation, proliferation, metabolism and apoptosis. Their function transcends normal physiology and extends into several pathological entities including cancer. The matrix metalloproteinases play pivotal roles, not only in tissue remodeling, but also in several physiological and pathological processes, including those supporting cancer progression. Additionally, the contribution of active MMPs in metastatic spread and the establishment of secondary metastasis, via the targeting of several substrates, are also well established. This review focuses on the important miRNAs that have been found to impact cancer progression and metastasis through direct and indirect interactions with the matrix metalloproteinases.
Keywords: microRNAs; MMPs; cancer; metastasis microRNAs; MMPs; cancer; metastasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abba, M.; Patil, N.; Allgayer, H. MicroRNAs in the Regulation of MMPs and Metastasis. Cancers 2014, 6, 625-645.

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