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Cancers 2014, 6(1), 416-435; doi:10.3390/cancers6010416
Review

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

1,2
,
2
 and
2,*
1 Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA 2 Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USA
* Author to whom correspondence should be addressed.
Received: 25 December 2013 / Revised: 7 February 2014 / Accepted: 8 February 2014 / Published: 17 February 2014
(This article belongs to the Special Issue Matrix Metalloproteinases in Cancer Progress)
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Abstract

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors.
Keywords: MT1-MMP; MMP-14; matrix metalloproteinases; CD44; collagen; metastasis MT1-MMP; MMP-14; matrix metalloproteinases; CD44; collagen; metastasis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pahwa, S.; Stawikowski, M.J.; Fields, G.B. Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression. Cancers 2014, 6, 416-435.

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