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Cancers 2014, 6(1), 416-435; doi:10.3390/cancers6010416
Review

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

1,2
,
2
 and
2,*
1 Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA 2 Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USA
* Author to whom correspondence should be addressed.
Received: 25 December 2013 / Revised: 7 February 2014 / Accepted: 8 February 2014 / Published: 17 February 2014
(This article belongs to the Special Issue Matrix Metalloproteinases in Cancer Progress)
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Abstract

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors.
Keywords: MT1-MMP; MMP-14; matrix metalloproteinases; CD44; collagen; metastasis MT1-MMP; MMP-14; matrix metalloproteinases; CD44; collagen; metastasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pahwa, S.; Stawikowski, M.J.; Fields, G.B. Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression. Cancers 2014, 6, 416-435.

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