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Cancers 2014, 6(1), 416-435; doi:10.3390/cancers6010416
Review

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

1,2
, 2
 and 2,*
Received: 25 December 2013; in revised form: 7 February 2014 / Accepted: 8 February 2014 / Published: 17 February 2014
(This article belongs to the Special Issue Matrix Metalloproteinases in Cancer Progress)
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Abstract: Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors.
Keywords: MT1-MMP; MMP-14; matrix metalloproteinases; CD44; collagen; metastasis MT1-MMP; MMP-14; matrix metalloproteinases; CD44; collagen; metastasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pahwa, S.; Stawikowski, M.J.; Fields, G.B. Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression. Cancers 2014, 6, 416-435.

AMA Style

Pahwa S, Stawikowski MJ, Fields GB. Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression. Cancers. 2014; 6(1):416-435.

Chicago/Turabian Style

Pahwa, Sonia; Stawikowski, Maciej J.; Fields, Gregg B. 2014. "Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression." Cancers 6, no. 1: 416-435.



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