Special Issue "Organo-Fluorine Chemical Science"

Quicklinks

A special issue of Applied Sciences (ISSN 2076-3417).

Deadline for manuscript submissions: closed (15 January 2012)

Special Issue Editor

Guest Editor
Dr. Helmut Martin Hügel
School of Applied Sciences (Chemistry), RMIT University, Melbourne VIC 3001, PO Box 2476V, Australia
E-Mail: helmut.hugel@rmit.edu.au
Phone: +61 3 99252626
Fax: +61 3 99253747
Interests: clinical and medicinal chemistry; chinese herbal medicine; chemical synthesis of natural and bioactive products; greener chemistry; sustainable chemistry; fragrance chemistry; microwave chemistry

Special Issue Information

Marine

Printed Edition Availble

A printed edition of this special issue is available:
website
Image credit to: EMSL
(ISBN 3-906980-33-2)

Special Issue
Organo-Fluorine Chemical Science
Inventing the Fluorine Future
2012
Helmut Martin Hügel (Ed.)
ISBN 3-906980-33-2

Dear Colleagues,

The unique properties imparted on molecules by fluorine substitution, continues to be the subject of intense research as the products have widespread application in all areas of science. Incorporation of fluorine can productively and unpredictably modulate several properties that interest medicinal chemists. Selected drugs for the treatment of high cholesterol such as LipitorⓇ by Pfizer, CrestorⓇ by AstraZeneca, ZetiaⓇ by Merck/Schering-Plough and LescolⓇ by Novartis all of which contain one or more fluorine atoms that increase metabolic stability, rank amongst the highest selling prescription drugs ever developed. Without doubt every current drug discovery and development program includes and evaluates fluorine-containing drug candidates. A one step 18F-labeling of peptides that contain a specific arene group has emerged that is rapid and simple to perform for 18F PET (positron emission tomography) an in vivo imaging technology for medical use has potential wide application. The synthesis of many pharmaceuticals and agrochemicals with fluorine atoms or groups is closely dependent on the development of new chemical methodologies by organic and industrial chemists. Monofluoroalkenes are known as nonisomerable, nonhydrolyzable stable bioisosteres of amide bonds and recently published highly enantio- and diastereoselective organocatalytic monofluorovinylations reactions have led to the isolation of monofluorovinylated products. A practical methodology for the enatioselective a-fluorination of ketene enolates has been optimized by the utilization of a three-component catalysis system provides an array of a-fluorocarboxylic acid derivatives. A generally useful coupling protocol for copper-catalyzed 1H-perfluoroalkane arylation by aryl iodides allows ready access to a range of perfluoroalkyl substituted aromatic compounds. Tetrafluoroethylene (TFE) is the organofluorine feedstock for the production of poly-(tetrafluoroethylene)polymers that have many applications. The transformation of TFE to a,b,b,-trifluorostyrenes via palladium-catalyzed coupling and arylzincs has been achieved in excellent yields and paves the way to new fluorine-polymers. The deployment of a fluorine substituted conjugated polymer in photovoltaic cells exhibited medium band gap yields above 7% attributed in part to the increased hole mobility of the fluorinated polymer. Organo-fluorine chemistry has had an enormous global impact on science and society, the fluorine fever continues to flourish and grow and we are delighted that experts in this field have agreed to contribute their research achievements to this special issue.

Dr. Helmut Martin Hügel
Guest Editor

Keywords

  • fluorinated drugs
  • fluorine-medicinal chemistry
  • perfluorinated heterocycles
  • fluorous mixture synthesis
  • fluorine-chemical biology
  • fluorine-chemistry
  • fluorine-toxicology
  • fluorine-industry
  • fluorine-products

Published Papers (18 papers)

Download All Papers
Sort by:
Display options:
Select articles Export citation of selected articles as:
Select/unselect all
Displaying article 1-18
p. 558-565
by  and
Appl. Sci. 2012, 2(2), 558-565; doi:10.3390/app2020558
Received: 25 May 2012; Accepted: 25 May 2012 / Published: 4 June 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (203 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 496-512
by
Appl. Sci. 2012, 2(2), 496-512; doi:10.3390/app2020496
Received: 23 April 2012; in revised form: 3 May 2012 / Accepted: 14 May 2012 / Published: 29 May 2012
Show/Hide Abstract | Cited by 7 | PDF Full-text (217 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 453-464
by ,  and
Appl. Sci. 2012, 2(2), 453-464; doi:10.3390/app2020453
Received: 15 February 2012; in revised form: 24 April 2012 / Accepted: 2 May 2012 / Published: 8 May 2012
Show/Hide Abstract | Cited by 13 | PDF Full-text (725 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
abstract graphic
p. 443-452
by  and
Appl. Sci. 2012, 2(2), 443-452; doi:10.3390/app2020443
Received: 5 April 2012; in revised form: 27 April 2012 / Accepted: 27 April 2012 / Published: 4 May 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (300 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 368-374
by ,  and
Appl. Sci. 2012, 2(2), 368-374; doi:10.3390/app2020368
Received: 29 January 2012; in revised form: 6 April 2012 / Accepted: 9 April 2012 / Published: 18 April 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (248 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 351-367
by , , ,  and
Appl. Sci. 2012, 2(2), 351-367; doi:10.3390/app2020351
Received: 21 February 2012; in revised form: 27 March 2012 / Accepted: 27 March 2012 / Published: 11 April 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (521 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 327-341
by ,  and
Appl. Sci. 2012, 2(2), 327-341; doi:10.3390/app2020327
Received: 13 March 2012; in revised form: 22 March 2012 / Accepted: 26 March 2012 / Published: 10 April 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (294 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
abstract graphic
p. 277-302
by , , , ,  and
Appl. Sci. 2012, 2(2), 277-302; doi:10.3390/app2020277
Received: 9 February 2012; in revised form: 8 March 2012 / Accepted: 19 March 2012 / Published: 28 March 2012
Show/Hide Abstract | Cited by 12 | PDF Full-text (628 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 245-259
by , ,  and
Appl. Sci. 2012, 2(2), 245-259; doi:10.3390/app2020245
Received: 14 January 2012; in revised form: 13 March 2012 / Accepted: 14 March 2012 / Published: 23 March 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (1250 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
abstract graphic
p. 233-244
by , , ,  and
Appl. Sci. 2012, 2(1), 233-244; doi:10.3390/app2010233
Received: 30 January 2012; in revised form: 20 February 2012 / Accepted: 10 March 2012 / Published: 19 March 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (599 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
abstract graphic
p. 206-219
by ,  and
Appl. Sci. 2012, 2(1), 206-219; doi:10.3390/app2010206
Received: 14 February 2012; in revised form: 22 February 2012 / Accepted: 28 February 2012 / Published: 6 March 2012
Show/Hide Abstract | Cited by 13 | PDF Full-text (5398 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 192-205
by , ,  and
Appl. Sci. 2012, 2(1), 192-205; doi:10.3390/app2010192
Received: 18 January 2012; in revised form: 24 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (1918 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 175-191
by  and
Appl. Sci. 2012, 2(1), 175-191; doi:10.3390/app2010175
Received: 16 January 2012; in revised form: 15 February 2012 / Accepted: 21 February 2012 / Published: 1 March 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (1655 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 129-138
by , , ,  and
Appl. Sci. 2012, 2(1), 129-138; doi:10.3390/app2010129
Received: 14 January 2012; in revised form: 7 February 2012 / Accepted: 13 February 2012 / Published: 24 February 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (346 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
abstract graphic
p. 114-128
by , , ,  and
Appl. Sci. 2012, 2(1), 114-128; doi:10.3390/app2010114
Received: 23 January 2012; in revised form: 10 February 2012 / Accepted: 14 February 2012 / Published: 23 February 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (391 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
abstract graphic
p. 61-99
by , , , , , ,  and
Appl. Sci. 2012, 2(1), 61-99; doi:10.3390/app2010061
Received: 6 December 2011; in revised form: 12 January 2012 / Accepted: 16 January 2012 / Published: 1 February 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (645 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 46-60
by  and
Appl. Sci. 2012, 2(1), 46-60; doi:10.3390/app2010046
Received: 26 December 2011; in revised form: 18 January 2012 / Accepted: 20 January 2012 / Published: 31 January 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (357 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
p. 24-34
by  and
Appl. Sci. 2012, 2(1), 24-34; doi:10.3390/app2010024
Received: 9 December 2011; in revised form: 4 January 2012 / Accepted: 5 January 2012 / Published: 16 January 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (682 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
Select/unselect all
Displaying article 1-18
Select articles Export citation of selected articles as:

Last update: 20 February 2014

Appl. Sci. EISSN 2076-3417 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert