Appl. Sci. 2012, 2(2), 277-302; doi:10.3390/app2020277
Review

Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges

1,* email, 2email, 2email, 2email, 3email and 2,* email
Received: 9 February 2012; in revised form: 8 March 2012 / Accepted: 19 March 2012 / Published: 28 March 2012
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Silicon-[18F]fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-18F and boron-18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodologies are driven by the demand for more convenient 18F-labeling procedures to further disseminate one of the most sophisticated imaging technologies, Positron Emission Tomography (PET). The PET methodology requires special radionuclides such as 18F (one of the most prominent examples) to be introduced into bioactive molecules. Si-18F radiochemistry contributed greatly towards the development of new radiopharmaceuticals for PET imaging. Herein, we describe the radiochemical basics of Si-18F bond formation, the application of Si-18F tracers for PET imaging, and additionally, the inherent chemical intricacies of this methodology.
Keywords: fluorine-18; silicon; positron emission tomography (PET)
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MDPI and ACS Style

Wängler, C.; Kostikov, A.; Zhu, J.; Chin, J.; Wängler, B.; Schirrmacher, R. Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges. Appl. Sci. 2012, 2, 277-302.

AMA Style

Wängler C, Kostikov A, Zhu J, Chin J, Wängler B, Schirrmacher R. Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges. Applied Sciences. 2012; 2(2):277-302.

Chicago/Turabian Style

Wängler, Carmen; Kostikov, Alexey; Zhu, Jun; Chin, Joshua; Wängler, Björn; Schirrmacher, Ralf. 2012. "Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges." Appl. Sci. 2, no. 2: 277-302.

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