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Appl. Sci. 2012, 2(2), 368-374; doi:10.3390/app2020368
Article

Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol

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Received: 29 January 2012; in revised form: 6 April 2012 / Accepted: 9 April 2012 / Published: 18 April 2012
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
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Abstract: This article describes one-pot synthesis of new fluorinated hexahydroquinoline derivatives via unsymmetric Hantzsch reaction involving 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol (TFE). The reaction is simple and rapid with high yield.
Keywords: unsymmetric Hantzsch reaction; dihydropyridine; trifluoromethyl; hexahydroquinoline; acridinedione; trifluoroethanol unsymmetric Hantzsch reaction; dihydropyridine; trifluoromethyl; hexahydroquinoline; acridinedione; trifluoroethanol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Okoro, C.O.; Ogunwale, M.A.; Siddiquee, T. Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol. Appl. Sci. 2012, 2, 368-374.

AMA Style

Okoro CO, Ogunwale MA, Siddiquee T. Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol. Applied Sciences. 2012; 2(2):368-374.

Chicago/Turabian Style

Okoro, Cosmas O.; Ogunwale, Mumiye A.; Siddiquee, Tasneem. 2012. "Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol." Appl. Sci. 2, no. 2: 368-374.


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