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Appl. Sci. 2012, 2(2), 368-374; doi:10.3390/app2020368
Article

Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol

* ,
 and
Department of Chemistry, Tennessee State University, Nashville, TN 37209, USA
* Author to whom correspondence should be addressed.
Received: 29 January 2012 / Revised: 6 April 2012 / Accepted: 9 April 2012 / Published: 18 April 2012
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
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Abstract

This article describes one-pot synthesis of new fluorinated hexahydroquinoline derivatives via unsymmetric Hantzsch reaction involving 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol (TFE). The reaction is simple and rapid with high yield.
Keywords: unsymmetric Hantzsch reaction; dihydropyridine; trifluoromethyl; hexahydroquinoline; acridinedione; trifluoroethanol unsymmetric Hantzsch reaction; dihydropyridine; trifluoromethyl; hexahydroquinoline; acridinedione; trifluoroethanol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Okoro, C.O.; Ogunwale, M.A.; Siddiquee, T. Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol. Appl. Sci. 2012, 2, 368-374.

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