Next Article in Journal / Special Issue
Computational Study on the Acid Catalyzed Reactions of Fluorine-Containing 2,4-Dialkoxy-3,4-dihydro-2H-pyrans with Aromatic Compounds
Previous Article in Journal
The Logic-Based Supervisor Control for Sun-Tracking System of 1 MW HCPV Demo Plant: Study Case
Previous Article in Special Issue
Novel Fluorinated Indanone, Tetralone and Naphthone Derivatives: Synthesis and Unique Structural Features
Appl. Sci. 2012, 2(1), 114-128; doi:10.3390/app2010114

A Study of Fluorinated β-Nitrostyrenes as Antimicrobial Agents

Health Innovations Research Institute & School of Applied Sciences, RMIT University, Melbourne, 3001 Australia
* Author to whom correspondence should be addressed.
Received: 23 January 2012 / Revised: 10 February 2012 / Accepted: 14 February 2012 / Published: 23 February 2012
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
View Full-Text   |   Download PDF [391 KB, uploaded 23 February 2012]   |  


The effect of variously fluorine-substituted β-methyl-β-nitrostyrenes on their antimicrobial activity was investigated. Their efficacy was determined by minimum inhibition concentration (MIC) in cultures of Gram positive and Gram negative bacteria and a fungus. Highest activity against the Gram negative bacterium, E.coli, was achieved with 4-fluorine-aryl substituted β-methyl-β-nitrostyrenes, while most compounds gave excellent results against gram positive bacteria. Importantly, the addition of the β-methyl group profoundly enhanced the antibacterial activity of the compounds tested. The comparative KD values for the most potent compounds against E.coli were much lower than those required for the gram positive and fungus counterparts. This investigation illustrated that fluorine substituted nitropropenylarenes have enhanced antimicrobial activity suitable for antibiotic applications.
Keywords: antimicrobial agents; Henry reaction; fluoro-β-methyl-β-nitrostyrenes; MIC; partition coefficients; log P values antimicrobial agents; Henry reaction; fluoro-β-methyl-β-nitrostyrenes; MIC; partition coefficients; log P values
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Lo, K.; Cornell, H.; Nicoletti, G.; Jackson, N.; Hügel, H. A Study of Fluorinated β-Nitrostyrenes as Antimicrobial Agents. Appl. Sci. 2012, 2, 114-128.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Appl. Sci. EISSN 2076-3417 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert